The Association of the Polymorphisms in the FUT8 -Related Locus with the Plasma Glycosylation in Post-Traumatic Stress Disorder

• Published in: International journal of molecular sciences Vol. 24; no. 6; p. 5706
• Main Authors: Tudor, Lucija, Nedic Erjavec, Gordana, Nikolac Perkovic, Matea, Konjevod, Marcela, Uzun, Suzana, Kozumplik, Oliver, Mimica, Ninoslav, Lauc, Gordan, Svob Strac, Dubravka, Pivac, Nela
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 16.03.2023; MDPI
• Subjects: Abnormalities; Alleles; Alternations; Autoimmune diseases; Body mass index; Cytotoxicity; Discriminant analysis; Fucose - metabolism; fucosyltransferase 8 (FUT8); Fucosyltransferases - genetics; Fucosyltransferases - metabolism; FUT8 gene; FUT8-related polymorphisms; Genomes; Glycan; Glycoproteins; Glycoproteins - metabolism; Glycosylation; Growth factors; haplotype; Haplotypes; Humans; Mental disorders; Metabolism; Metastasis; N-glycans; Plasma; Plasma levels; Polymorphism; Polysaccharides - metabolism; Post traumatic stress disorder; Post-translation; Psychological stress; Stress Disorders, Post-Traumatic - genetics; post-traumatic stress disorder; haplotype; FUT8-related polymorphisms; glycosylation; N-glycans; fucosyltransferase 8 (FUT8); plasma
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms24065706

The molecular underpinnings of post-traumatic stress disorder (PTSD) are still unclear due to the complex interactions of genetic, psychological, and environmental factors. Glycosylation is a common post-translational modification of proteins, and different pathophysiological states, such as inflammation, autoimmune diseases, and mental disorders including PTSD, show altered N-glycome. Fucosyltransferase 8 (FUT8) is the enzyme that catalyzes the addition of core fucose on glycoproteins, and mutations in the gene are associated with defects in glycosylation and functional abnormalities. This is the first study that investigated the associations of plasma N-glycan levels with -related rs6573604, rs11621121, rs10483776, and rs4073416 polymorphisms and their haplotypes in 541 PTSD patients and control participants. The results demonstrated that the rs6573604 T allele was more frequent in the PTSD than in the control participants. Significant associations of plasma N-glycan levels with PTSD and -related polymorphisms were observed. We also detected associations of rs11621121 and rs10483776 polymorphisms and their haplotypes with plasma levels of specific N-glycan species in both the control and PTSD groups. In carriers of different rs6573604 and rs4073416 genotypes and alleles, differences in plasma N-glycan levels were only found in the control group. These molecular findings suggest a possible regulatory role of -related polymorphisms in glycosylation, the alternations of which could partially explain the development and clinical manifestation of PTSD.