Cell-mediated immune response in Indian kala azar and post-kala azar dermal leishmaniasis

• Published in: Infection and Immunity Vol. 42; no. 2; pp. 702 - 707
• Main Authors: Haldar, J.P, Ghose, S, Saha, K.C, Ghose, A.C
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.11.1983
• Subjects: Adult; Biological and medical sciences; cell-mediated immunity; Child; Dermatology; Enzyme-Linked Immunosorbent Assay; Female; Human protozoal diseases; Humans; Hypersensitivity, Delayed; immune response; immunity; Immunity, Cellular; Immunity, Skin tests; immunocompetence; Immunoglobulin G - analysis; Immunoglobulin M - analysis; immunoglobulins; India; Infectious diseases; Leishmania donovani; Leishmaniasis - immunology; Leishmaniasis, Visceral - immunology; Leshmaniasis; Lymphocyte Activation; lymphocytes; Lymphocytes - immunology; Male; Medical sciences; Middle Aged; Parasitic diseases; Protozoal diseases; Skin involvement in other diseases. Miscellaneous. General aspects; Skin Tests; Tropical medicine; India; Infection; Skin disease; Protozoal disease; Immunology; Asia; Cell immunity; Kala azar; Skin; Leishmaniasis; India
• ISSN: 0019-9567; 1098-5522
• DOI: 10.1128/iai.42.2.702-707.1983

Indian kala azar (KA) and post-kala azar dermal leishmaniasis, cell-mediated immune (CMI) status determined by in vitro lymphocyte transformation experiments and by in vivo skin testing, results show impairment of CMI response in active KA which appears to be more specific to leishmania than generalized in nature, restoration of specific T-cell responsiveness was aided by antileishmanial drug therapy which resulted in reduction of antigenic load by parasite destruction and concomitant decrease in circulating antibody levels, particularly that of IgG class