NK cell-based cancer immunotherapy： from basic biology to clinical application

Natural killer（NK） cells, which recognize and kill target cells independent of antigen specificity and major histocompatibility complex（MHC） matching, play pivotal roles in immune defence against tumors. However, tumor cells often acquire the ability to escape NK cell-mediated immune surveillance. T...

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Published inScience China. Life Sciences Vol. 58; no. 12; pp. 1233 - 1245
Main Authors Li, Yang, Yin, Jie, Li, Ting, Huang, Shan, Yan, Han, Leavenworth, JianMei, Wang, Xi
Format Journal Article Book Review
LanguageEnglish
Published Beijing Science China Press 01.12.2015
Springer Nature B.V
Subjects
Adaptive Immunity - immunology
Biomedical and Life Sciences
Cell Communication - immunology
Clinical Trials as Topic
Dendritic Cells - immunology
Humans
Immunity, Innate - immunology
Immunotherapy, Adoptive - methods
Killer Cells, Natural - immunology
Life Sciences
Neoplasms - immunology
Neoplasms - therapy
NK细胞
Review
T-Lymphocytes - immunology
临床应用
主要组织相容性复合体
免疫治疗
分子机制
基础生物学
抗原特异性
抗肿瘤
cytokine infusion
cancer
adoptive transfer
NK cell
immunotherapy
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Summary:Natural killer（NK） cells, which recognize and kill target cells independent of antigen specificity and major histocompatibility complex（MHC） matching, play pivotal roles in immune defence against tumors. However, tumor cells often acquire the ability to escape NK cell-mediated immune surveillance. Thus, understanding mechanisms underlying regulation of NK cell phenotype and function within the tumor environment is instrumental for designing new approaches to improve the current cell-based immunotherapy. In this review, we elaborate the main biological features and molecular mechanisms of NK cells that pertain to regulation of NK cell-mediated anti-tumor activity. We further overview current clinical approaches regarding NK cell-based cancer therapy, including cytokine infusion, adoptive transfer of autologous or allogeneic NK cells, applications of chimeric antigen receptor（CAR）-expressing NK cells and adoptive transfer of memory-like NK cells. With these promising clinical outcomes and fuller understanding the basic questions raised in this review, we foresee that NK cell-based approaches may hold great potential for future cancer immunotherapy.
Bibliography:Natural killer（NK） cells, which recognize and kill target cells independent of antigen specificity and major histocompatibility complex（MHC） matching, play pivotal roles in immune defence against tumors. However, tumor cells often acquire the ability to escape NK cell-mediated immune surveillance. Thus, understanding mechanisms underlying regulation of NK cell phenotype and function within the tumor environment is instrumental for designing new approaches to improve the current cell-based immunotherapy. In this review, we elaborate the main biological features and molecular mechanisms of NK cells that pertain to regulation of NK cell-mediated anti-tumor activity. We further overview current clinical approaches regarding NK cell-based cancer therapy, including cytokine infusion, adoptive transfer of autologous or allogeneic NK cells, applications of chimeric antigen receptor（CAR）-expressing NK cells and adoptive transfer of memory-like NK cells. With these promising clinical outcomes and fuller understanding the basic questions raised in this review, we foresee that NK cell-based approaches may hold great potential for future cancer immunotherapy.
11-5841/Q
NK cell,cancer,cytokine infusion,adoptive transfer,immunotherapy
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1674-7305
1869-1889
DOI:10.1007/s11427-015-4970-9