Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug
In the early 1980s, it became apparent that the work of pioneers such as Robert Weinberg, Mariano Barbacid and many others in identifying cancer-causing genes in humans was opening the door to a new era in anticancer research. Motivated by this, and by dissatisfaction with the limited efficacy and t...
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Published in | Nature reviews. Drug discovery Vol. 1; no. 7; pp. 493 - 502 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
England
Nature Publishing Group
01.07.2002
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Subjects | |
Online Access | Get full text |
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Summary: | In the early 1980s, it became apparent that the work of pioneers such as Robert Weinberg, Mariano Barbacid and many others in identifying cancer-causing genes in humans was opening the door to a new era in anticancer research. Motivated by this, and by dissatisfaction with the limited efficacy and tolerability of available anticancer modalities, a drug discovery programme was initiated with the aim of rationally developing targeted anticancer therapies. Here, we describe how this programme led to the discovery and continuing development of Glivec (Gleevec in the United States), the first selective tyrosine-kinase inhibitor to be approved for the treatment of a cancer. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 1474-1776 1474-1784 1474-1784 |
DOI: | 10.1038/nrd839 |