Natural killer T cells in bronchial biopsies from human allergen challenge model of allergic asthma

At baseline, the mean number of iNKT cells/mm2 of lung biopsy was 33 (range, 13-40) in patients with allergic asthma compared with none in the healthy control samples (P < .003; Fig 1, C). [...]9.8% (range, 5-20) of CD3+ cells were iNKT cells compared with controls, in whom no iNKT cells were ide...

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Published inJournal of allergy and clinical immunology Vol. 124; no. 4; pp. 860 - 862
Main Authors Reynolds, Catherine, PhD, Barkans, Julia, BSc, Clark, Peter, PhD, Kariyawasam, Harsha, MD, PhD, Altmann, Daniel, PhD, Kay, Barry, MD, PhD, Boyton, Rosemary, MD, PhD
Format Journal Article
LanguageEnglish
Published United States Mosby, Inc 01.10.2009
Elsevier Limited
Subjects
Allergens - immunology
Allergies
Allergy and Immunology
Asthma
Asthma - immunology
Asthma - pathology
Bronchi - immunology
Bronchi - pathology
Bronchial Provocation Tests
Drug therapy
Humans
Lymphocyte Count
Natural Killer T-Cells - immunology
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Summary:At baseline, the mean number of iNKT cells/mm2 of lung biopsy was 33 (range, 13-40) in patients with allergic asthma compared with none in the healthy control samples (P < .003; Fig 1, C). [...]9.8% (range, 5-20) of CD3+ cells were iNKT cells compared with controls, in whom no iNKT cells were identified (P < .04).
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ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2009.07.022