Neuromodulation effects of deep brain stimulation on beta rhythm: A longitudinal local field potential study

• Published in: Brain stimulation Vol. 13; no. 6; pp. 1784 - 1792
• Main Authors: Chen, Yue, Gong, Chen, Tian, Ye, Orlov, Natasza, Zhang, Jianguo, Guo, Yi, Xu, Shujun, Jiang, Changqing, Hao, Hongwei, Neumann, Wolf-Julian, Kühn, Andrea A., Liu, Hesheng, Li, Luming
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2020; Elsevier
• Subjects: Basal ganglia; Beta oscillation; Beta Rhythm - physiology; Chronic effects; Deep brain stimulation; Deep Brain Stimulation - methods; Female; Follow-Up Studies; Humans; Longitudinal Studies; Male; Middle Aged; Neural Pathways - diagnostic imaging; Neural Pathways - physiology; Parkinson Disease - diagnostic imaging; Parkinson Disease - physiopathology; Parkinson Disease - therapy; Parkinson's disease; Subthalamic nucleus; Subthalamic Nucleus - diagnostic imaging; Subthalamic Nucleus - physiology; PSD; Basal ganglia; Beta oscillation; Parkinson's disease; DBS; Deep brain stimulation; LFP; TEED; UPDRS; Subthalamic nucleus; STN; Chronic effects
• ISSN: 1935-861X; 1876-4754; 1876-4754
• DOI: 10.1016/j.brs.2020.09.027

Deep brain stimulation (DBS) holds great promise in treating various brain diseases but its chronic therapeutic mechanisms are unclear. To explore the immediate and chronic effects of DBS on brain oscillations, and understand how different sub-bands of oscillations may be related to symptom improvement in Parkinson's patients. We carried out a longitudinal study to examine the effects of DBS on local field potentials recorded by sensing-enabled neurostimulators in the subthalamic nuclei of Parkinson's patients, using a novel block-design stimulation paradigm. DBS significantly suppressed beta activity (13–35Hz) but the suppression effect appeared to gradually attenuate during a 6-month follow-up period after surgery (p = 0.002). However, beta suppression did not attenuate after repeated stimulation over several minutes (p > 0.110), suggesting that the changes in beta suppression may reflect a slow reconfiguration of neural pathways instead of habituation. Suppression of beta was also associated with clinical symptom improvement across subjects. Importantly, symptom-relevant features fell within the high beta band at month 1 but shifted to the low beta band at month 6, indicating that the high beta and the low beta oscillations may play different functional roles and respond differently to stimulation over the long-term treatment. These data may advance understanding of chronic DBS effects on beta oscillations and their association with clinical improvement, offering novel insights to the therapeutic mechanisms of DBS. •DBS suppresses beta activity but the suppression effect gradually attenuates.•The beta suppression does not habituate after short-term repeated stimulation.•Spontaneous beta band power did not show significant changes after chronic stimulation.•Chronic clinical improvement is related to the modulation of low beta band.