Factors influencing disproportionate replication of the ribosomal RNA cistrons in Drosophila melanogaster

• Published in: Genetics (Austin) Vol. 107; no. 3; pp. 395 - 404
• Main Authors: Dutton, F.L, Krider, H.M
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Genetics Soc America 01.07.1984; Genetics Society of America
• Subjects: animal breeding; animal genetics; Animals; arthropods; Biological and medical sciences; DNA - biosynthesis; DNA Replication; DNA, Ribosomal; Dosage Compensation, Genetic; Drosophila melanogaster; Drosophila melanogaster - genetics; Drosophilidae; entomology; Female; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation; Genes; Genotype; Investigations; Male; Molecular and cellular biology; Molecular genetics; Replication; RNA, Ribosomal - biosynthesis; X Chromosome; Gene dosage; Cistron; Ribosomal RNA; Arthropoda; Insecta; Replication; X-Chromosome; Invertebrata; Drosophila melanogaster; Diptera
• ISSN: 0016-6731; 1943-2631; 1943-2631
• DOI: 10.1093/genetics/107.3.395

This report describes studies of the compensatory response employing D. melanogaster stocks that bear cloned-X chromosomes derived from laboratory populations of strains Oregon R and Canton S. We find that modification of the autosomal background in either the female or the XY male parent influences the expression of the compensatory response by X chromosomes derived from the Canton S population, whereas Oregon R isolates are unresponsive to these effects. We have also studied compensatory replication in X/O larvae produced from cloned-X derivatives of both Canton S and Oregon R. Canton S larval compensation exceeds that of the adult, whereas in Oregon R the converse is true. We have concluded that both X chromosomal and autosomal factors affect the expression and magnitude of the compensatory response.