Nerve root magnetic stimulation improves locomotor function following spinal cord injury with electrophysiological improvements and cortical synaptic reconstruction

• Published in: Neural regeneration research Vol. 17; no. 9; pp. 2036 - 2042
• Main Authors: Zheng, Ya, Zhao, Dan, Xue, Dong-Dong, Mao, Ye-Ran, Cao, Ling-Yun, Zhang, Ye, Zhu, Guang-Yue, Yang, Qi, Xu, Dong-Sheng
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.09.2022; Medknow Publications & Media Pvt. Ltd; Department of Rehabilitation Medicine,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai,China; Rehabilitation Engineering Research Center for Integrated Traditional Chinese and Western Medicine,Ministry of Education,Shanghai,China+Department of Rehabilitation Medicine,Ruijin Hospital Affiliated to Shanghai Jiao Tong University,Shanghai,China; Department of Rehabilitation,Tongji Hospital,School of Medicine,Tongji University,Shanghai,China%Department of Hepatobiliary Surgery,Hebei General Hospital,Shijiazhuang,Hebei Province,China%Department of Rehabilitation,Baoshan Branch,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,China%School of Rehabilitation Science,Shanghai University of Traditional Chinese Medicine,Shanghai,China%Department of Rehabilitation,The Sixth People's Hospital Affiliated to Shanghai Jiao Tong University,Shanghai,China%School of Rehabilitation Science,Shanghai University of Traditional Chinese Medicine,Shanghai,China; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: evoked potentials; h-reflex; motor activity; nerve conduction; neural plasticity; rehabilitation; sensorimotor cortex; spinal cord injury; synapses; transcranial magnetic stimulation; Spinal cord injuries; spinal cord injury; rehabilitation; synapses; sensorimotor cortex; H-reflex; neural plasticity; transcranial magnetic stimulation; nerve conduction; evoked potentials; motor activity
• ISSN: 1673-5374; 1876-7958
• DOI: 10.4103/1673-5374.335161

Following a spinal cord injury, there are usually a number of neural pathways that remain intact in the spinal cord. These residual nerve fibers are important, as they could be used to reconstruct the neural circuits that enable motor function. Our group previously designed a novel magnetic stimulation protocol, targeting the motor cortex and the spinal nerve roots, that led to significant improvements in locomotor function in patients with a chronic incomplete spinal cord injury. Here, we investigated how nerve root magnetic stimulation contributes to improved locomotor function using a rat model of spinal cord injury. Rats underwent surgery to clamp the spinal cord at T10; three days later, the rats were treated with repetitive magnetic stimulation (5 Hz, 25 pulses/train, 20 pulse trains) targeting the nerve roots at the L5-L6 vertebrae. The treatment was repeated five times a week over a period of three weeks. We found that the nerve root magnetic stimulation improved the locomotor function and enhanced nerve conduction in the injured spinal cord. In addition, the nerve root magnetic stimulation promoted the recovery of synaptic ultrastructure in the sensorimotor cortex. Overall, the results suggest that nerve root magnetic stimulation may be an effective, noninvasive method for mobilizing the residual spinal cord pathways to promote the recovery of locomotor function.