Cortical network dynamics during source memory retrieval: Current density imaging with individual MRI

• Published in: Human brain mapping Vol. 30; no. 1; pp. 78 - 91
• Main Authors: Kim, Young Youn, Roh, Ah Young, Namgoong, Yoon, Jo, Hang Joon, Lee, Jong-Min, Kwon, Jun Soo
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.01.2009; Wiley-Liss
• Subjects: Acoustic Stimulation; Action Potentials - physiology; Adolescent; Adult; Biological and medical sciences; Brain Mapping; Cerebral Cortex - anatomy & histology; Cerebral Cortex - physiology; Data Interpretation, Statistical; ERPs; Evoked Potentials - physiology; Female; Functional Laterality - physiology; Fundamental and applied biological sciences. Psychology; Human; Humans; Investigative techniques, diagnostic techniques (general aspects); Learning. Memory; LORETA; Magnetic Resonance Imaging - methods; Male; Medical sciences; Memory; Memory - physiology; multiple neural systems; Nerve Net - anatomy & histology; Nerve Net - physiology; Nervous system; Neural Pathways - anatomy & histology; Neural Pathways - physiology; Neurons - physiology; Neuropsychological Tests; old/new effect; Parietal Lobe - anatomy & histology; Parietal Lobe - physiology; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Reaction Time; Signal Processing, Computer-Assisted; source memory retrieval; statistical parametric mapping; Young Adult; Current source; ERPs; Cartography; Memory retrieval; multiple neural systems; source memory retrieval; Nervous system diseases; old/new effect; Radiodiagnosis; LORETA; Nuclear magnetic resonance imaging; statistical parametric mapping
• ISSN: 1065-9471; 1097-0193; 1097-0193
• DOI: 10.1002/hbm.20487

We investigated the neural correlates of source memory retrieval using low‐resolution electromagnetic tomography (LORETA) with 64 channels EEG and individual MRI as a realistic head model. Event‐related potentials (ERPs) were recorded while 13 healthy subjects performed the source memory task for the voice of the speaker in spoken words. The source correct condition of old words elicited more positive‐going potentials than the correct rejection condition of new words at 400–700 ms post‐stimulus and the old/new effects also appeared in the right anterior region between 1,000 and 1,200 ms. We conducted source reconstruction at mean latencies of 311, 604, 793, and 1,100 ms and used statistical parametric mapping for the statistical analysis. The results of source analysis suggest that the activation of the right inferior parietal region may reflect retrieval of source information. The source elicited by the difference ERPs between the source correct and source incorrect conditions exhibited dynamic change of current density activation in the overall cortices with time during source memory retrieval. These results indicate that multiple neural systems may underlie the ability to recollect context. Hum Brain Mapp 2009. © 2007 Wiley‐Liss, Inc.