Role of Adipose Tissue as an Inflammatory Organ in Human Diseases

Reviews on the inflammatory role of adipose tissue outside the field of metabolism are rare. There is increasing evidence provided by numerous basic research studies from nearly all internal medicine subspecializations that adipocytes and adipocytokines are involved in primary inflammatory processes...

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Bibliographic Details
Published inEndocrine reviews Vol. 27; no. 5; pp. 449 - 467
Main Authors Schäffler, A, Müller-Ladner, U, Schölmerich, J, Büchler, C
Format Journal Article
LanguageEnglish
Published Bethesda, MD Endocrine Society 01.08.2006
Copyright by The Endocrine Society
Subjects
Adipocytes - physiology
Adipose Tissue - growth & development
Adipose Tissue - immunology
Adipose Tissue - physiology
Animals
Biological and medical sciences
Cytokines - physiology
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Humans
Immune System Diseases - etiology
Immune System Diseases - genetics
Inflammation - etiology
Inflammation - immunology
Mesenchymal Stromal Cells - physiology
Models, Biological
Vertebrates: endocrinology
Human
Adipose tissue
Review
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Summary:Reviews on the inflammatory role of adipose tissue outside the field of metabolism are rare. There is increasing evidence provided by numerous basic research studies from nearly all internal medicine subspecializations that adipocytes and adipocytokines are involved in primary inflammatory processes and diseases. Therefore, it is the aim of the present review to discuss and to summarize the current knowledge on the inflammatory role of adipocytokines and special types of regional adipocytes such as retroorbital, synovial, visceral, subdermal, peritoneal, and bone marrow adipocytes in internal medicine diseases. Future clinical and therapeutic implications are discussed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0163-769X
1945-7189
DOI:10.1210/er.2005-0022