STUDY ON SUBACUTE TOXICITY OF INTRAVENOUS SORBITAN TRIOLEATE (STO) IN WISTAR RATS

Subacute toxicity of STO was carried out using Wistar rats. STO was administered intravenously at dose levels of 12.5, 50.0 and 200.0 mg/kg for 35 days. No influence on general symptom, body weight, food and water consumption and urinalysis were observed. In 200.0 mg/kg group, the hematological exam...

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Published inJournal of toxicological sciences Vol. 8; no. 4; pp. 301 - 310
Main Authors YAMAMOTO, Hiroaki, TSUTSUI, Kazuo, SHIMADA, Kaoru, YAMANISHI, Yasuhito, IMAI, Shunsuke
Format Journal Article
LanguageEnglish
Published Tokyo The Japanese Society of Toxicology 1983
Japanese Society of Toxicology
Japan Science and Technology Agency
Subjects
Animals
Biological and medical sciences
Bone Marrow - pathology
Female
General pharmacology
Hexoses - toxicity
Liver - pathology
Male
Medical sciences
Organ Size - drug effects
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Rats
Rats, Inbred Strains
Spleen - pathology
Surface-Active Agents - toxicity
Thromboembolism - chemically induced
Wistar rats
Vertebrata
Mammalia
Intravenous administration
Rat
Toxicity
Non ionic surfactant
Rodentia
Solvent
Subacute
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Summary:Subacute toxicity of STO was carried out using Wistar rats. STO was administered intravenously at dose levels of 12.5, 50.0 and 200.0 mg/kg for 35 days. No influence on general symptom, body weight, food and water consumption and urinalysis were observed. In 200.0 mg/kg group, the hematological examination revealed anemia corresponding to the histological findings of the bone marrow. Biochemical analysis displayed the significant increase and/or decrease of enzyme values in 200.0 mg/kg group. Morphology showed the swelling, vacuolization and granuloma of the spleen, hepatic granuloma, the increase of reticulum cells and granuloma in the bone marrow. Embolism and thrombus were also found in the pulmonaly and tail veins probably due to an artifact caused by the i. v. injection. The toxicity of the STO were observed only in 200.0 mg/kg group of both sexes and any remarkable change other than physical effects were found in other groups under the above dosage. Accordingly, the maximal no-effect level of the STO in Wistar rats was considered to be 50.0 mg/kg.
ISSN:0388-1350
1880-3989
DOI:10.2131/jts.8.301