Enantioselective Symmetry Breaking Directed by the Order of Process Steps

Going forward in reverse: The configuration of the product of grinding‐induced symmetry breaking can be controlled simply by the order in which the different reaction‐mixture components are combined (see scheme: I) glass beads, II) racemic mixture (enantiomers differentiated by color), III) solvent,...

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Published inAngewandte Chemie (International ed.) Vol. 49; no. 14; pp. 2539 - 2541
Main Authors Noorduin, Wim L, Meekes, Hugo, van Enckevort, Willem J.P, Kaptein, Bernard, Kellogg, Richard M, Vlieg, Elias
Format Journal Article
LanguageEnglish
Published Weinheim Wiley-VCH Verlag 29.03.2010
WILEY-VCH Verlag
WILEY‐VCH Verlag
Subjects
additives
chiral resolution
crystal growth
Crystallization
dissolution
Models, Molecular
Molecular Structure
Solutions - chemistry
Stereoisomerism
symmetry breaking
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Summary:Going forward in reverse: The configuration of the product of grinding‐induced symmetry breaking can be controlled simply by the order in which the different reaction‐mixture components are combined (see scheme: I) glass beads, II) racemic mixture (enantiomers differentiated by color), III) solvent, IV) racemization catalyst). The underlying mechanism is based on a subtle balance between enantioselective crystal growth and dissolution.
Bibliography:http://dx.doi.org/10.1002/anie.200907231
ArticleID:ANIE200907231
The SNN agency (Cooperation Northern Netherlands) and the European Fund for Regional Development (EFRO) are acknowledged for partial financial support of this research. The group from Radboud University Nijmegen thank COST Action CM0703 for support.
istex:AA1BDDEB3C9164CD57CD8D0089D6BC5AEF8EF3A8
ark:/67375/WNG-K7QWB9TQ-L
European Fund for Regional Development (EFRO)
COST Action - No. CM0703
SNN agency
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200907231