Enantioselective Symmetry Breaking Directed by the Order of Process Steps
Going forward in reverse: The configuration of the product of grinding‐induced symmetry breaking can be controlled simply by the order in which the different reaction‐mixture components are combined (see scheme: I) glass beads, II) racemic mixture (enantiomers differentiated by color), III) solvent,...
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Published in | Angewandte Chemie (International ed.) Vol. 49; no. 14; pp. 2539 - 2541 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
Wiley-VCH Verlag
29.03.2010
WILEY-VCH Verlag WILEY‐VCH Verlag |
Subjects | |
Online Access | Get full text |
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Summary: | Going forward in reverse: The configuration of the product of grinding‐induced symmetry breaking can be controlled simply by the order in which the different reaction‐mixture components are combined (see scheme: I) glass beads, II) racemic mixture (enantiomers differentiated by color), III) solvent, IV) racemization catalyst). The underlying mechanism is based on a subtle balance between enantioselective crystal growth and dissolution. |
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Bibliography: | http://dx.doi.org/10.1002/anie.200907231 ArticleID:ANIE200907231 The SNN agency (Cooperation Northern Netherlands) and the European Fund for Regional Development (EFRO) are acknowledged for partial financial support of this research. The group from Radboud University Nijmegen thank COST Action CM0703 for support. istex:AA1BDDEB3C9164CD57CD8D0089D6BC5AEF8EF3A8 ark:/67375/WNG-K7QWB9TQ-L European Fund for Regional Development (EFRO) COST Action - No. CM0703 SNN agency ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1433-7851 1521-3773 |
DOI: | 10.1002/anie.200907231 |