miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells

• Published in: Cancer letters Vol. 347; no. 1; pp. 98 - 104
• Main Authors: Liu, Jingjing, Wang, Xu, Yang, Xiaoning, Liu, Yunpeng, Shi, Ying, Ren, Jianlin, Guleng, Bayasi
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 28.05.2014; Elsevier Limited
• Subjects: Apoptosis; Base Sequence; beta Catenin - metabolism; Cell growth; Cell Line, Tumor; Cell Proliferation; Cyclin D - metabolism; DNA Primers; Expression regulation; Gastric cancer; Gene expression; Hematology, Oncology and Palliative Medicine; Humans; MicroRNAs; MicroRNAs - physiology; miR-423-5p; Neoplasm Invasiveness; Phase transitions; Polymerase Chain Reaction; Proliferation and invasion; Proteins; Rodents; Stomach Neoplasms - genetics; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; Trefoil factor 1 (TFF1); Trefoil Factor-1; Tumor Suppressor Proteins - physiology; Tumors; China; Proliferation and invasion; miR-423-5p; Trefoil factor 1 (TFF1); Gastric cancer; Expression regulation
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2014.01.024

Abstract TFF1 is a small, secreted protein in the TFF family that has a pivotal role as a motogenic factor in epithelial restitution and cell motility, and as a tumor suppressor gene in the stomach. In this study, we identified TFF1 as a novel target gene of miRNA-423-5p. miRNA-423-5p negatively regulated the expression of TFF1 by binding to its 3′UTR and participated in proliferation/invasion-related processes via a TFF1-dependent manner in gastric cancer cells. Our findings suggested that miR-423-5p may be a novel target for the future development of specific therapeutic interventions for gastric cancer.