The Inflammatory Role of Platelets: Translational Insights from Experimental Studies of Autoimmune Disorders

• Published in: International journal of molecular sciences Vol. 17; no. 10; p. 1723
• Main Authors: Pankratz, Susann, Bittner, Stefan, Kehrel, Beate E, Langer, Harald F, Kleinschnitz, Christoph, Meuth, Sven G, Göbel, Kerstin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.10.2016; MDPI
• Subjects: Animals; Arthritis, Rheumatoid - immunology; Arthritis, Rheumatoid - pathology; Autoimmune diseases; Autoimmune Diseases - immunology; Autoimmune Diseases - pathology; autoimmunity; Blood platelets; Blood Platelets - immunology; Blood Platelets - pathology; Genetics; Humans; Inflammation - immunology; Inflammation - pathology; Inflammatory Bowel Diseases - immunology; Inflammatory Bowel Diseases - pathology; Inflammatory diseases; Multiple Sclerosis - immunology; Multiple Sclerosis - pathology; neuroinflammation; Pharmacology; platelets; Review; autoimmunity; neuroinflammation; platelets
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms17101723

Beyond their indispensable role in hemostasis, platelets have shown to affect the development of inflammatory disorders, as they have been epidemiologically and mechanistically linked to diseases featuring an inflammatory reaction in inflammatory diseases like multiple sclerosis, rheumatoid arthritis and inflammatory bowel disorders. The identification of novel molecular mechanisms linking inflammation and to platelets has highlighted them as new targets for therapeutic interventions. In particular, genetic and pharmacological studies have identified an important role for platelets in neuroinflammation. This review summarizes the main molecular links between platelets and inflammation, focusing on immune regulatory factors, receptors, cellular targets and signaling pathways by which they can amplify inflammatory reactions and that make them potential therapeutic targets.