Mechanisms underlying obesity resistance associated with high spontaneous physical activity

• Published in: Neuroscience Vol. 256; pp. 91 - 100
• Main Authors: Teske, J.A, Billington, C.J, Kotz, C.M
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier 03.01.2014
• Subjects: Age Factors; Animals; Benzazepines - pharmacology; Benzoxazoles - pharmacology; Biological and medical sciences; Body Weight - drug effects; Dopamine Antagonists - pharmacology; Eating - drug effects; Electromyography; Eye Movements - drug effects; Fundamental and applied biological sciences. Psychology; Hypothalamus - drug effects; Hypothalamus - physiology; Intracellular Signaling Peptides and Proteins - pharmacology; Male; Medical sciences; Metabolic diseases; Motor Activity - drug effects; Motor Activity - physiology; Neurology; Neuropeptides - pharmacology; Obesity; Obesity - physiopathology; Orexin Receptor Antagonists; Orexins; Rats; Rats, Sprague-Dawley; Sleep - drug effects; Substantia Nigra - drug effects; Substantia Nigra - physiology; Urea - analogs & derivatives; Urea - pharmacology; Vertebrates: nervous system and sense organs; Wakefulness - drug effects; slow wave sleep; obesity resistant; SPA; lateral hypothalamus; dopamine one receptor; OXR; rostral lateral hypothalamus; rapid eye movement; electromyogram; orexin A; analysis of variance; ANOVA; orexin receptor; spontaneous physical activity; SN; EMG; reward; active wake; DA1R; OP; obesity prone; substantia nigra; OR; EEG; electroencephalogram; SWS; diet-induced obesity; rLH; AW; hypocretin; OXA; locomotor activity; REM; Obesity; Central nervous system; Nutrition disorder; Lateral hypothalamus; Feeding; Encephalon; Locomotion; Spontaneous physical activity; Diet; Reward; Nutritional status; Orexin
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2013.10.028

Highlights • OX1R and DA1R antagonists reduced OXA-induced SPA more effectively in lean rats. • OXA increased arousal equally in lean and obese rodents. • OR rats ran more and wheel running was directly related to 24-h SPA levels.