A Study on Mortality Predictors in Hemodialysis Patients Infected with COVID-19: Impact of Vaccination Status

• Published in: Vaccines (Basel) Vol. 12; no. 1; p. 2
• Main Authors: Brkovic, Voin, Nikolic, Gorana, Baralic, Marko, Kravljaca, Milica, Milinkovic, Marija, Pavlovic, Jelena, Lausevic, Mirjana, Radovic, Milan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 19.12.2023; MDPI
• Subjects: Analysis; C-reactive protein; chronic kidney disease; Comorbidity; Coronaviruses; COVID-19; COVID-19 vaccines; Drug dosages; Epidemics; Evaluation; Ferritin; Hazard identification; Hemodialysis; Hemodialysis patients; Hemorrhage; Hospitals; Infections; Inflammation; Kidney diseases; Leukocytes; lymphocytopenia; Lymphopenia; Mortality; Normal distribution; Pandemics; Patient outcomes; Patients; Pneumonia; Public health; Regression analysis; Respiratory diseases; Severe acute respiratory syndrome coronavirus 2; Thromboembolism; Thrombosis; Vaccination; vaccines; Viral diseases; Serbia; United States > US; COVID-19; hemodialysis; chronic kidney disease; lymphocytopenia; vaccines
• ISSN: 2076-393X; 2076-393X
• DOI: 10.3390/vaccines12010002

The global outbreak of COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has prompted significant public health concerns. This study focuses on 442 chronic hemodialysis patients diagnosed with COVID-19, emphasizing the impact of vaccination status on clinical outcomes. The study investigates the correlation between vaccination status and laboratory findings, aiming to identify predictive factors for mortality. Results indicate that vaccination status plays a crucial role in outcomes. Full vaccination, evidenced by two or three doses, is associated with better outcomes, including reduced incidence of bilateral pneumonia and lower risks of complications such as hemorrhage and thrombosis. Laboratory analyses reveal significant differences between vaccinated and unvaccinated patients in parameters like C-reactive protein, ferritin, and white blood cell counts. Univariate and multivariate Cox proportional hazards regression analyses identify several factors influencing mortality, including comorbidities, pneumonia development, and various inflammatory markers. In conclusion among hemodialysis patients affected by COVID-19 infection, vaccination with at least three doses emerges as a protective factor against fatal outcomes. Independent predictors of mortality are CRP levels upon admission, maximum CRP values during the illness and cardiovascular comorbidities. Noteworthy lymphocytopenia during infection exhibits a notable level of specificity and sensitivity in predicting mortality.