A cytotoxic and cytostatic gold(iii) corrole

• Published in: Chemical communications (Cambridge, England) Vol. 5; no. 89; pp. 13789 - 13792
• Main Authors: Teo, Ruijie D, Gray, Harry B, Lim, Punnajit, Termini, John, Domeshek, Elena, Gross, Zeev
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 01.01.2014
• Subjects: Affinity; Analogue; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Cancer; Cell Line, Tumor; Cell Survival - drug effects; Chemistry; Chemistry, Multidisciplinary; Cytostatic Agents - chemistry; Cytostatic Agents - pharmacology; Cytotoxins - chemistry; Cytotoxins - pharmacology; Gallium - chemistry; Gallium - pharmacology; Gold - chemistry; Gold - pharmacology; Humans; Ligands; Organogold Compounds - chemistry; Organogold Compounds - pharmacology; Physical Sciences; Porphyrins - chemistry; Porphyrins - pharmacology; Science & Technology; Serum albumin; Serum Albumin - chemistry; Serum Albumin - metabolism; Synthesis; Toxicity; REACTIVITY; COMPLEXES; GROWTH
• ISSN: 1359-7345; 1364-548X
• DOI: 10.1039/c4cc06577h

We have synthesized and characterized a water-soluble gold( iii ) corrole ( 1-Au ) that is highly toxic to cisplatin-resistant cancer cells. Relative to its 1-Ga analogue, axial ligands bind only weakly to 1-Au , which likely accounts for its lower affinity for human serum albumin (HSA). We suggest that the cytotoxicity of 1-Au may be related to this lower HSA affinity. The bis-sulfonated Au( iii ) corrole ( 1-Au ) was found to be much more cytotoxic and cytostatic than its Ga( iii ) analog 1-Ga , which might be attributed to the lower affinity of 1-Au to serum albumin.