Ameliorating effects of rolipram on experimentally induced impairments of learning and memory in rodents

• Published in: European journal of pharmacology Vol. 321; no. 3; pp. 273 - 278
• Main Authors: Imanishi, Taiichiro, Sawa, Aiko, Ichimaru, Yasuyuki, Miyashiro, Mio, Kato, Shinsuke, Yamamoto, Tsuneyuki, Ueki, Showa
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 05.03.1997; Elsevier
• Subjects: 3-Panel runway; Animals; Avoidance Learning - drug effects; Biological and medical sciences; Brain Ischemia - physiopathology; Bucladesine - pharmacology; cAMP; Cyclic AMP - metabolism; Electroshock - adverse effects; Learning; Learning - drug effects; Male; Medical sciences; Memory; Memory - drug effects; Mice; Motor Activity - drug effects; Neuropharmacology; Passive avoidance; Pharmacology. Drug treatments; Phosphodiesterase Inhibitors - pharmacology; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Pyrrolidinones - pharmacology; Rats; Rats, Wistar; Rolipram; Scopolamine - toxicity; Learning; Rolipram; cAMP; Memory; Passive avoidance; 3-Panel runway; Memory disorder; Rat; Psychotropic; Esterases; Cognition; Phosphoric diester hydrolases; Antidepressant agent; Amnesia; Behavior; Neurological disorder; Mechanism of action; Nervous system diseases; 3',5'-Cyclic-nucleotide phosphodiesterase; Enzyme; Rodentia; Cyclic AMP; Enzyme inhibitor; Cerebral disorder; Vertebrata; Chemotherapy; Experimental disease; Mammalia; Treatment; Mouse; Animal; Central nervous system disease; Hydrolases
• ISSN: 0014-2999; 1879-0712
• DOI: 10.1016/S0014-2999(96)00969-7

The effects of rolipram, a cAMP-specific phosphodiesterase (phosphodiesterase 4) inhibitor, on experimentally-induced amnesia were examined using a 3-panel runway paradigm in rats and a passive avoidance task in mice. Scopolamine, cerebral ischemia induced by four-vessel occlusion and electric convulsive shock impaired working memory in the 3-panel runway task. Rolipram at 0.1 mg/kg reduced the increase in errors induced by scopolamine or cerebral ischemia. Rolipram at 0.32 mg/kg also reduced the increase in errors induced by electric convulsive shock. Dibutyryl cAMP also had similar effects in 3-panel runway experiments. In the passive avoidance task, rolipram reversed the impairments of the avoidance response induced by scopolamine, cycloheximide and electric convulsive shock at 10, 10 and 3 mg/kg, respectively. These results indicate that rolipram ameliorates impairments of learning and memory in rats and mice, and suggest that rolipram might ameliorate the impairments of learning and memory by elevating cAMP levels.