Abnormal Dynamic Reconfiguration of Multilayer Temporal Networks in Patients with Bipolar Disorder

• Published in: Brain sciences Vol. 14; no. 9; p. 935
• Main Authors: Lai, Luyao, Li, Dandan, Zhang, Yating, Hao, Jianchao, Wang, Xuedong, Cui, Xiaohong, Xiang, Jie, Wang, Bin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.09.2024; MDPI
• Subjects: Bipolar disorder; Brain; Care and treatment; dynamic reconfiguration; Functional magnetic resonance imaging; inter-layer coupling; Magnetic resonance imaging; Memory; Mental disorders; multilayer temporal network; Network switching; Neuroimaging; phase coherence; Recruitment; Time series; multilayer temporal network; bipolar disorder; dynamic reconfiguration; phase coherence; inter-layer coupling
• ISSN: 2076-3425; 2076-3425
• DOI: 10.3390/brainsci14090935

Background: Multilayer networks have been used to identify abnormal dynamic reconfiguration in bipolar disorder (BD). However, these studies ignore the differences in information interactions between adjacent layers when constructing multilayer networks, and the analysis of dynamic reconfiguration is not comprehensive enough; Methods: Resting-state functional magnetic resonance imaging data were collected from 46 BD patients and 54 normal controls. A multilayer temporal network was constructed for each subject, and inter-layer coupling of different nodes was considered using network similarity. The promiscuity, recruitment, and integration coefficients were calculated to quantify the different dynamic reconfigurations between the two groups; Results: The global inter-layer coupling, recruitment, and integration coefficients were significantly lower in BD patients. These results were further observed in the attention network and the limbic/paralimbic and subcortical network, reflecting reduced temporal stability, intra- and inter-subnetwork communication abilities in BD patients. The whole-brain promiscuity was increased in BD patients. The same results were observed in the somatosensory/motor and auditory network, reflecting more functional interactions; Conclusions: This study discovered abnormal dynamic interactions of BD from the perspective of dynamic reconfiguration, which can help to understand the pathological mechanisms of BD.