Understanding and exploiting interactions between cellular proteostasis pathways and infectious prion proteins for therapeutic benefit

Several neurodegenerative diseases of humans and animals are caused by the misfolded prion protein (PrP ), a self-propagating protein infectious agent that aggregates into oligomeric, fibrillar structures and leads to cell death by incompletely understood mechanisms. Work in multiple biological mode...

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Published inOpen biology Vol. 10; no. 11; p. 200282
Main Authors Yakubu, Unekwu M, Catumbela, Celso S G, Morales, Rodrigo, Morano, Kevin A
Format Journal Article
LanguageEnglish
Published England The Royal Society 01.11.2020
Subjects
human
prions
protein chaperones
protein misfolding
Review
stress
yeast
stress
prions
protein chaperones
human
protein misfolding
yeast
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Abstract Several neurodegenerative diseases of humans and animals are caused by the misfolded prion protein (PrP ), a self-propagating protein infectious agent that aggregates into oligomeric, fibrillar structures and leads to cell death by incompletely understood mechanisms. Work in multiple biological model systems, from simple baker's yeast to transgenic mouse lines, as well as studies, has illuminated molecular and cellular modifiers of prion disease. In this review, we focus on intersections between PrP and the proteostasis network, including unfolded protein stress response pathways and roles played by the powerful regulators of protein folding known as protein chaperones. We close with analysis of promising therapeutic avenues for treatment enabled by these studies.
AbstractList Several neurodegenerative diseases of humans and animals are caused by the misfolded prion protein (PrP Sc ), a self-propagating protein infectious agent that aggregates into oligomeric, fibrillar structures and leads to cell death by incompletely understood mechanisms. Work in multiple biological model systems, from simple baker's yeast to transgenic mouse lines, as well as in vitro studies, has illuminated molecular and cellular modifiers of prion disease. In this review, we focus on intersections between PrP and the proteostasis network, including unfolded protein stress response pathways and roles played by the powerful regulators of protein folding known as protein chaperones. We close with analysis of promising therapeutic avenues for treatment enabled by these studies.
Several neurodegenerative diseases of humans and animals are caused by the misfolded prion protein (PrP ), a self-propagating protein infectious agent that aggregates into oligomeric, fibrillar structures and leads to cell death by incompletely understood mechanisms. Work in multiple biological model systems, from simple baker's yeast to transgenic mouse lines, as well as studies, has illuminated molecular and cellular modifiers of prion disease. In this review, we focus on intersections between PrP and the proteostasis network, including unfolded protein stress response pathways and roles played by the powerful regulators of protein folding known as protein chaperones. We close with analysis of promising therapeutic avenues for treatment enabled by these studies.
Several neurodegenerative diseases of humans and animals are caused by the misfolded prion protein (PrPSc), a self-propagating protein infectious agent that aggregates into oligomeric, fibrillar structures and leads to cell death by incompletely understood mechanisms. Work in multiple biological model systems, from simple baker's yeast to transgenic mouse lines, as well as in vitro studies, has illuminated molecular and cellular modifiers of prion disease. In this review, we focus on intersections between PrP and the proteostasis network, including unfolded protein stress response pathways and roles played by the powerful regulators of protein folding known as protein chaperones. We close with analysis of promising therapeutic avenues for treatment enabled by these studies.
Author Morano, Kevin A
Catumbela, Celso S G
Yakubu, Unekwu M
Morales, Rodrigo
AuthorAffiliation 3 Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, McGovern Medical School at UTHealth , Houston, TX USA
2 MD Anderson UTHealth Graduate School at UTHealth , Houston, TX USA
4 Centro integrativo de biología y química aplicada (CIBQA), Universidad Bernardo O'Higgins , Santiago , Chile
1 Department of Microbiology and Molecular Genetics, McGovern Medical School at UTHealth , Houston, TX USA
AuthorAffiliation_xml – name: 1 Department of Microbiology and Molecular Genetics, McGovern Medical School at UTHealth , Houston, TX USA
– name: 2 MD Anderson UTHealth Graduate School at UTHealth , Houston, TX USA
– name: 3 Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, McGovern Medical School at UTHealth , Houston, TX USA
– name: 4 Centro integrativo de biología y química aplicada (CIBQA), Universidad Bernardo O'Higgins , Santiago , Chile
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  givenname: Unekwu M
  surname: Yakubu
  fullname: Yakubu, Unekwu M
  organization: MD Anderson UTHealth Graduate School at UTHealth, Houston, TX USA
– sequence: 2
  givenname: Celso S G
  surname: Catumbela
  fullname: Catumbela, Celso S G
  organization: Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, McGovern Medical School at UTHealth, Houston, TX USA
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  givenname: Rodrigo
  surname: Morales
  fullname: Morales, Rodrigo
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  fullname: Morano, Kevin A
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/33234071$$D View this record in MEDLINE/PubMed
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CitedBy_id crossref_primary_10_1016_j_jbc_2021_100567
Cites_doi 10.1292/jvms.64.855
10.1099/vir.0.80375-0
10.3389/fmolb.2015.00057
10.1371/journal.pone.0117412
10.1212/WNL.41.3.375
10.1073/pnas.0808934105
10.1074/jbc.M115.700393
10.1371/journal.pone.0182143
10.1093/brain/awv235
10.4161/pri.1.2.4346
10.3389/fnins.2019.01154
10.3389/fvets.2016.00078
10.1212/01.wnl.0000266624.63387.4a
10.1371/journal.pone.0026319
10.1007/BF00143124
10.1016/S0140-6736(00)02785-9
10.1136/vr.131.19.431
10.1073/pnas.95.23.13363
10.1038/nm1782
10.1038/nrm2204
10.1083/jcb.201505104
10.1042/BSR20140058
10.1038/nature06384
10.1126/science.1209126
10.1007/978-0-387-39975-1_9
10.1074/jbc.M112214200
10.1093/ilar/ilv008
10.1242/jeb.090738
10.1093/brain/aws366
10.1016/j.molcel.2015.07.012
10.1093/brain/awx107
10.1091/mbc.e08-01-0078
10.1101/cshperspect.a023663
10.1016/S1097-2765(00)80330-5
10.1007/s00401-017-1782-y
10.1016/0021-9975(68)90006-6
10.1016/0968-0004(94)90281-X
10.1083/jcb.153.5.1061
10.1073/pnas.0910342106
10.1038/s41467-020-16566-1
10.1038/38925
10.1007/s00018-004-4464-6
10.4161/pri.28938
10.1016/j.neuro.2006.06.004
10.1016/0092-8674(89)90058-5
10.1038/s41551-019-0349-8
10.1098/rstb.1994.0036
10.1146/annurev.bi.55.070186.005443
10.1101/cshperspect.a023531
10.1006/jmbi.2001.4852
10.1016/S0092-8674(00)81223-4
10.1074/jbc.M605320200
10.1073/pnas.050010197
10.1016/j.biocel.2019.105680
10.1371/journal.pgen.1000507
10.1016/B978-0-444-63945-5.00010-6
10.7554/eLife.30700
10.1021/acs.langmuir.9b01645
10.1002/1531-8249(200002)47:2<257::AID-ANA20>3.0.CO;2-U
10.3892/etm.2017.4832
10.3346/jkms.2010.25.7.1097
10.1007/s00401-012-1002-8
10.1016/S0021-9258(18)43837-9
10.1083/jcb.152.3.553
10.1038/cddis.2015.49
10.1073/pnas.0504400102
10.1016/S1097-2765(00)80412-8
10.1523/JNEUROSCI.0203-11.2011
10.1038/nprot.2012.067
10.1523/JNEUROSCI.4090-04.2005
10.1074/jbc.M111547200
10.1111/j.1742-4658.2010.07827.x
10.1016/j.bbadis.2006.12.006
10.1177/104063870701900202
10.1007/s00418-003-0524-5
10.1016/S1097-2765(01)00265-9
10.1074/jbc.RA119.008822
10.1091/mbc.10.11.3787
10.1007/s004150070048
10.1016/S0304-3940(02)01071-6
10.1021/ar0301678
10.1101/cshperspect.a024349
10.1534/genetics.108.089458
10.1016/0092-8674(93)90635-4
10.1006/bbrc.1993.2466
10.3201/eid2406.172007
10.1016/j.tibs.2008.12.009
10.1371/journal.pone.0015658
10.1371/journal.pone.0087521
10.1111/boc.201900045
10.1016/j.celrep.2014.09.056
10.1186/s12883-017-0886-2
10.1074/jbc.RA118.006186
10.1016/j.bbamcr.2010.03.005
10.1038/nrm1247
10.1038/nature07761
10.1542/peds.2013-1396
10.1073/pnas.0811571106
10.1002/ana.21420
10.1038/labinvest.3700676
10.1016/j.jmb.2015.11.016
10.1002/1531-8249(199908)46:2<224::AID-ANA12>3.0.CO;2-W
10.1021/bi900108v
10.1073/pnas.0502066102
10.1126/scitranslmed.3006767
10.1007/s002940000180
10.1093/genetics/144.4.1375
10.1016/S0092-8674(00)80928-9
10.1128/MCB.20.23.8916-8922.2000
10.1038/nsmb.3277
10.1128/MCB.21.14.4656-4669.2001
10.1016/S1357-2725(98)00091-0
10.1038/cddis.2016.384
10.1126/science.7754373
10.1016/j.tibs.2006.01.002
10.1371/journal.ppat.1002589
10.1152/physrev.00006.2009
10.14252/foodsafetyfscj.2016018
10.1136/vr.129.11.233
10.1371/journal.pone.0191490
10.1016/S0006-8993(03)03045-2
10.1101/gad.13.10.1211
10.1093/genetics/156.2.559
10.1111/j.1365-2990.2007.00868.x
10.1038/emboj.2012.264
10.1073/pnas.0711094105
10.1038/22241
10.1128/JB.176.24.7476-7483.1994
10.1136/vr.130.17.365
10.1097/WAD.0000000000000049
10.1016/S0272-2712(02)00070-7
10.1091/mbc.e17-01-0070
10.1016/B978-0-444-63945-5.00001-5
10.1128/MCB.13.2.1034
10.1074/jbc.M110636200
10.1016/S0076-6879(06)13017-7
10.1097/01.jnen.0000218445.30535.6f
10.1186/1743-422X-8-493
10.1093/brain/awv006
10.1046/j.1439-0442.2001.00312.x
10.1113/jphysiol.2007.142448
10.1136/vr.136.17.444
10.1093/hmg/ddy152
10.1038/s41551-019-0367-6
10.1038/sj.emboj.7600985
10.1038/mi.2012.105
10.1073/pnas.0606480103
10.1074/jbc.RA118.005980
10.1128/MCB.22.11.3590-3598.2002
10.1093/emboj/16.7.1501
10.1074/jbc.274.22.15712
10.1038/383685a0
10.1136/vr.135.13.296
10.1101/gad.12.24.3788
10.1080/19336896.2016.1254858
10.1146/annurev-animal-022114-111001
10.1016/S0003-3995(03)00017-0
10.1093/brain/awq234
10.1371/journal.ppat.1006323
10.1038/nature07195
10.1006/nbdi.2001.0418
10.1016/j.ejmech.2016.02.065
10.1212/WNL.41.9.1390
10.1128/MCB.23.17.6013-6026.2003
10.1038/srep20526
10.1371/journal.ppat.1002582
10.1186/s12915-017-0375-5
10.1038/srep44723
10.1371/journal.ppat.1003537
10.1038/nature03989
10.1073/pnas.98.4.1442
10.1074/jbc.M005543200
10.4161/pri.22212
10.1074/jbc.M611909200
10.1093/infdis/115.4.387
10.1128/JVI.74.12.5542-5547.2000
10.1074/jbc.270.35.20298
10.1126/science.1066838
10.1534/genetics.111.137760
10.1038/nrmicro.2015.4
10.1002/1531-8249(200010)48:4<665::AID-ANA15>3.0.CO;2-D
10.1098/rstb.2008.0068
10.3389/fncel.2019.00339
10.1007/s00294-019-01006-5
10.1083/jcb.201201074
10.1093/emboj/cdg537
10.1056/NEJM199905273402104
10.3390/pathogens6040067
10.1038/nrn1007
10.1128/MCB.23.21.7448-7459.2003
10.1515/hsz-2018-0209
10.1186/1471-2377-11-136
10.2527/2005.8361455x
10.1016/j.cub.2012.07.004
10.1002/yea.1062
10.1073/pnas.0710054104
10.1073/pnas.1813352116
10.1074/jbc.M405468200
10.1093/bmb/66.1.213
10.1099/vir.0.022103-0
10.1523/JNEUROSCI.3307-17.2018
10.1093/emboj/20.10.2435
10.20506/rst.11.2.611
10.1021/acschemneuro.9b00320
10.1074/jbc.M606856200
10.1074/jbc.M113.507491
10.1073/pnas.1212484110
10.1128/MMBR.00041-14
10.1016/j.molcel.2017.12.003
10.1016/j.febslet.2015.10.010
10.1074/jbc.274.43.30402
10.1212/WNL.52.9.1757
10.1006/scdb.1999.0320
10.1001/archneur.63.6.876
10.1128/JVI.70.7.4724-4728.1996
10.1007/978-1-4614-0653-2_6
10.1074/jbc.M307996200
10.1016/0002-9343(59)90251-7
10.1016/j.tibs.2008.09.010
10.1111/j.1742-4658.2010.07828.x
10.1128/MMBR.05018-11
10.1002/j.1460-2075.1996.tb00624.x
10.1128/MCB.19.12.8103
10.1091/mbc.e07-02-0128
10.1016/j.ejmech.2019.111753
10.1007/978-1-61779-295-3_3
10.1371/journal.pgen.1006431
10.1038/sj.cdd.4401840
10.1073/pnas.90.4.1315
10.5694/j.1326-5377.1957.tb60287.x
10.1111/febs.14422
10.1016/S0140-6736(06)68344-X
10.1038/nrn1587
10.1534/genetics.107.077982
10.1074/jbc.M807369200
10.3389/fmolb.2015.00010
10.1007/978-94-007-2774-8_10
10.1128/MCB.19.2.1325
10.1093/bmb/66.1.199
10.1111/j.1528-1157.1999.tb01583.x
10.1093/brain/122.12.2375
10.1038/s41593-018-0238-6
10.1371/journal.pone.0001763
10.15252/embj.201591245
10.1007/s00439-005-0020-1
10.1371/journal.pone.0003135
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Issue 11
Keywords stress
prions
protein chaperones
human
protein misfolding
yeast
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References e_1_3_5_27_2
e_1_3_5_65_2
e_1_3_5_88_2
e_1_3_5_104_2
e_1_3_5_142_2
e_1_3_5_165_2
e_1_3_5_188_2
e_1_3_5_80_2
Schenkein J (e_1_3_5_24_2) 2006; 8
e_1_3_5_191_2
e_1_3_5_240_2
e_1_3_5_42_2
e_1_3_5_9_2
e_1_3_5_202_2
e_1_3_5_248_2
e_1_3_5_225_2
e_1_3_5_39_2
e_1_3_5_16_2
e_1_3_5_131_2
e_1_3_5_139_2
e_1_3_5_54_2
e_1_3_5_77_2
e_1_3_5_116_2
e_1_3_5_154_2
e_1_3_5_177_2
e_1_3_5_92_2
e_1_3_5_252_2
e_1_3_5_180_2
e_1_3_5_31_2
e_1_3_5_237_2
e_1_3_5_214_2
e_1_3_5_28_2
e_1_3_5_120_2
e_1_3_5_43_2
e_1_3_5_66_2
e_1_3_5_89_2
e_1_3_5_128_2
e_1_3_5_105_2
e_1_3_5_143_2
e_1_3_5_189_2
e_1_3_5_166_2
e_1_3_5_81_2
e_1_3_5_241_2
e_1_3_5_192_2
e_1_3_5_8_2
e_1_3_5_249_2
e_1_3_5_203_2
e_1_3_5_226_2
e_1_3_5_17_2
Kirkwood JK (e_1_3_5_56_2) 1990; 127
e_1_3_5_32_2
e_1_3_5_55_2
e_1_3_5_193_2
e_1_3_5_78_2
e_1_3_5_117_2
e_1_3_5_132_2
e_1_3_5_155_2
e_1_3_5_178_2
Alberts B (e_1_3_5_127_2) 2002
e_1_3_5_93_2
e_1_3_5_230_2
e_1_3_5_253_2
e_1_3_5_70_2
e_1_3_5_181_2
e_1_3_5_238_2
e_1_3_5_215_2
e_1_3_5_148_2
e_1_3_5_25_2
Bradley R (e_1_3_5_13_2) 2006; 44
e_1_3_5_140_2
e_1_3_5_163_2
e_1_3_5_102_2
e_1_3_5_125_2
e_1_3_5_186_2
e_1_3_5_200_2
e_1_3_5_40_2
e_1_3_5_86_2
e_1_3_5_63_2
e_1_3_5_7_2
e_1_3_5_208_2
e_1_3_5_223_2
e_1_3_5_246_2
e_1_3_5_37_2
e_1_3_5_137_2
e_1_3_5_14_2
e_1_3_5_98_2
e_1_3_5_152_2
e_1_3_5_175_2
e_1_3_5_114_2
e_1_3_5_198_2
e_1_3_5_90_2
e_1_3_5_250_2
e_1_3_5_52_2
e_1_3_5_75_2
e_1_3_5_212_2
e_1_3_5_258_2
e_1_3_5_235_2
e_1_3_5_26_2
e_1_3_5_149_2
e_1_3_5_209_2
e_1_3_5_87_2
e_1_3_5_141_2
e_1_3_5_126_2
e_1_3_5_164_2
e_1_3_5_49_2
e_1_3_5_103_2
e_1_3_5_187_2
e_1_3_5_41_2
e_1_3_5_64_2
e_1_3_5_190_2
Henningfield JE (e_1_3_5_255_2) 2006; 172
e_1_3_5_201_2
e_1_3_5_224_2
e_1_3_5_247_2
e_1_3_5_6_2
e_1_3_5_38_2
e_1_3_5_15_2
e_1_3_5_138_2
e_1_3_5_130_2
e_1_3_5_76_2
e_1_3_5_99_2
e_1_3_5_153_2
e_1_3_5_176_2
e_1_3_5_199_2
e_1_3_5_115_2
e_1_3_5_91_2
e_1_3_5_251_2
e_1_3_5_53_2
e_1_3_5_30_2
e_1_3_5_213_2
e_1_3_5_236_2
e_1_3_5_100_2
e_1_3_5_123_2
e_1_3_5_146_2
e_1_3_5_169_2
e_1_3_5_23_2
e_1_3_5_108_2
e_1_3_5_161_2
e_1_3_5_46_2
e_1_3_5_69_2
e_1_3_5_244_2
e_1_3_5_221_2
e_1_3_5_61_2
e_1_3_5_84_2
e_1_3_5_206_2
e_1_3_5_229_2
e_1_3_5_5_2
e_1_3_5_112_2
e_1_3_5_135_2
e_1_3_5_158_2
e_1_3_5_12_2
e_1_3_5_35_2
e_1_3_5_150_2
e_1_3_5_196_2
e_1_3_5_173_2
e_1_3_5_58_2
e_1_3_5_233_2
e_1_3_5_210_2
e_1_3_5_50_2
e_1_3_5_73_2
e_1_3_5_96_2
Kirkwood JK (e_1_3_5_48_2) 1995; 26
e_1_3_5_218_2
e_1_3_5_256_2
e_1_3_5_101_2
e_1_3_5_147_2
e_1_3_5_109_2
e_1_3_5_185_2
e_1_3_5_162_2
e_1_3_5_47_2
e_1_3_5_124_2
e_1_3_5_222_2
e_1_3_5_62_2
e_1_3_5_85_2
e_1_3_5_207_2
e_1_3_5_4_2
e_1_3_5_245_2
e_1_3_5_136_2
e_1_3_5_36_2
e_1_3_5_159_2
e_1_3_5_151_2
e_1_3_5_174_2
e_1_3_5_59_2
e_1_3_5_197_2
e_1_3_5_113_2
e_1_3_5_211_2
e_1_3_5_51_2
e_1_3_5_97_2
e_1_3_5_74_2
e_1_3_5_219_2
e_1_3_5_234_2
e_1_3_5_257_2
e_1_3_5_121_2
Todorova TT (e_1_3_5_184_2) 2015; 21
e_1_3_5_21_2
e_1_3_5_44_2
e_1_3_5_106_2
e_1_3_5_129_2
e_1_3_5_182_2
e_1_3_5_144_2
e_1_3_5_167_2
e_1_3_5_29_2
Onodera T (e_1_3_5_67_2) 2019; 36
e_1_3_5_82_2
e_1_3_5_242_2
e_1_3_5_170_2
e_1_3_5_227_2
e_1_3_5_3_2
e_1_3_5_204_2
e_1_3_5_179_2
e_1_3_5_110_2
Liberski PP (e_1_3_5_45_2) 2009; 47
e_1_3_5_10_2
e_1_3_5_33_2
e_1_3_5_171_2
e_1_3_5_79_2
e_1_3_5_118_2
e_1_3_5_194_2
e_1_3_5_133_2
e_1_3_5_18_2
e_1_3_5_156_2
e_1_3_5_254_2
e_1_3_5_71_2
e_1_3_5_231_2
e_1_3_5_94_2
e_1_3_5_216_2
e_1_3_5_239_2
Takase KI (e_1_3_5_20_2) 2001; 41
e_1_3_5_122_2
e_1_3_5_168_2
e_1_3_5_22_2
e_1_3_5_160_2
e_1_3_5_68_2
e_1_3_5_107_2
e_1_3_5_183_2
e_1_3_5_145_2
e_1_3_5_220_2
e_1_3_5_243_2
e_1_3_5_2_2
e_1_3_5_60_2
e_1_3_5_83_2
e_1_3_5_205_2
e_1_3_5_228_2
e_1_3_5_157_2
e_1_3_5_111_2
e_1_3_5_34_2
e_1_3_5_11_2
e_1_3_5_172_2
e_1_3_5_195_2
e_1_3_5_119_2
e_1_3_5_57_2
e_1_3_5_19_2
e_1_3_5_134_2
e_1_3_5_232_2
e_1_3_5_72_2
e_1_3_5_95_2
e_1_3_5_217_2
References_xml – ident: e_1_3_5_43_2
  doi: 10.1292/jvms.64.855
– ident: e_1_3_5_75_2
  doi: 10.1099/vir.0.80375-0
– ident: e_1_3_5_228_2
  doi: 10.3389/fmolb.2015.00057
– ident: e_1_3_5_145_2
  doi: 10.1371/journal.pone.0117412
– ident: e_1_3_5_21_2
  doi: 10.1212/WNL.41.3.375
– ident: e_1_3_5_199_2
  doi: 10.1073/pnas.0808934105
– ident: e_1_3_5_200_2
  doi: 10.1074/jbc.M115.700393
– ident: e_1_3_5_142_2
  doi: 10.1371/journal.pone.0182143
– ident: e_1_3_5_18_2
  doi: 10.1093/brain/awv235
– ident: e_1_3_5_85_2
  doi: 10.4161/pri.1.2.4346
– ident: e_1_3_5_105_2
  doi: 10.3389/fnins.2019.01154
– ident: e_1_3_5_41_2
  doi: 10.3389/fvets.2016.00078
– ident: e_1_3_5_17_2
  doi: 10.1212/01.wnl.0000266624.63387.4a
– ident: e_1_3_5_226_2
  doi: 10.1371/journal.pone.0026319
– ident: e_1_3_5_5_2
  doi: 10.1007/BF00143124
– ident: e_1_3_5_15_2
  doi: 10.1016/S0140-6736(00)02785-9
– ident: e_1_3_5_51_2
  doi: 10.1136/vr.131.19.431
– ident: e_1_3_5_70_2
  doi: 10.1073/pnas.95.23.13363
– ident: e_1_3_5_114_2
  doi: 10.1038/nm1782
– volume: 8
  start-page: 66
  year: 2006
  ident: e_1_3_5_24_2
  article-title: Self-management of fatal familial insomnia. Part 2: case report
  publication-title: MedGenMed Medscape Gen. Med.
  contributor:
    fullname: Schenkein J
– ident: e_1_3_5_69_2
  doi: 10.1038/nrm2204
– ident: e_1_3_5_210_2
  doi: 10.1083/jcb.201505104
– ident: e_1_3_5_124_2
  doi: 10.1042/BSR20140058
– ident: e_1_3_5_126_2
  doi: 10.1038/nature06384
– ident: e_1_3_5_138_2
  doi: 10.1126/science.1209126
– ident: e_1_3_5_155_2
  doi: 10.1007/978-0-387-39975-1_9
– ident: e_1_3_5_132_2
  doi: 10.1074/jbc.M112214200
– ident: e_1_3_5_59_2
  doi: 10.1093/ilar/ilv008
– ident: e_1_3_5_121_2
  doi: 10.1242/jeb.090738
– ident: e_1_3_5_33_2
  doi: 10.1093/brain/aws366
– ident: e_1_3_5_229_2
  doi: 10.1016/j.molcel.2015.07.012
– ident: e_1_3_5_249_2
  doi: 10.1093/brain/awx107
– volume: 47
  start-page: 195
  year: 2009
  ident: e_1_3_5_45_2
  article-title: Transmissible mink encephalopathy: review of the etiology of a rare prion disease
  publication-title: Folia Neuropathol.
  contributor:
    fullname: Liberski PP
– ident: e_1_3_5_188_2
  doi: 10.1091/mbc.e08-01-0078
– ident: e_1_3_5_176_2
  doi: 10.1101/cshperspect.a023663
– start-page: 1
  volume-title: Molecular biology of the cell
  year: 2002
  ident: e_1_3_5_127_2
  contributor:
    fullname: Alberts B
– ident: e_1_3_5_141_2
  doi: 10.1016/S1097-2765(00)80330-5
– ident: e_1_3_5_100_2
  doi: 10.1007/s00401-017-1782-y
– ident: e_1_3_5_98_2
  doi: 10.1016/0021-9975(68)90006-6
– ident: e_1_3_5_167_2
  doi: 10.1016/0968-0004(94)90281-X
– ident: e_1_3_5_131_2
  doi: 10.1083/jcb.153.5.1061
– ident: e_1_3_5_147_2
  doi: 10.1073/pnas.0910342106
– ident: e_1_3_5_118_2
  doi: 10.1038/s41467-020-16566-1
– ident: e_1_3_5_14_2
  doi: 10.1038/38925
– ident: e_1_3_5_148_2
  doi: 10.1007/s00018-004-4464-6
– ident: e_1_3_5_247_2
  doi: 10.4161/pri.28938
– ident: e_1_3_5_74_2
  doi: 10.1016/j.neuro.2006.06.004
– ident: e_1_3_5_164_2
  doi: 10.1016/0092-8674(89)90058-5
– ident: e_1_3_5_257_2
  doi: 10.1038/s41551-019-0349-8
– ident: e_1_3_5_53_2
  doi: 10.1098/rstb.1994.0036
– ident: e_1_3_5_120_2
  doi: 10.1146/annurev.bi.55.070186.005443
– ident: e_1_3_5_180_2
  doi: 10.1101/cshperspect.a023531
– ident: e_1_3_5_225_2
  doi: 10.1006/jmbi.2001.4852
– ident: e_1_3_5_160_2
  doi: 10.1016/S0092-8674(00)81223-4
– ident: e_1_3_5_245_2
  doi: 10.1074/jbc.M605320200
– ident: e_1_3_5_134_2
  doi: 10.1073/pnas.050010197
– ident: e_1_3_5_77_2
  doi: 10.1016/j.biocel.2019.105680
– ident: e_1_3_5_239_2
  doi: 10.1371/journal.pgen.1000507
– ident: e_1_3_5_62_2
  doi: 10.1016/B978-0-444-63945-5.00010-6
– ident: e_1_3_5_137_2
  doi: 10.7554/eLife.30700
– ident: e_1_3_5_116_2
  doi: 10.1021/acs.langmuir.9b01645
– ident: e_1_3_5_2_2
  doi: 10.1002/1531-8249(200002)47:2<257::AID-ANA20>3.0.CO;2-U
– ident: e_1_3_5_9_2
  doi: 10.3892/etm.2017.4832
– ident: e_1_3_5_6_2
  doi: 10.3346/jkms.2010.25.7.1097
– ident: e_1_3_5_96_2
  doi: 10.1007/s00401-012-1002-8
– ident: e_1_3_5_173_2
  doi: 10.1016/S0021-9258(18)43837-9
– ident: e_1_3_5_171_2
  doi: 10.1083/jcb.152.3.553
– ident: e_1_3_5_253_2
  doi: 10.1038/cddis.2015.49
– ident: e_1_3_5_165_2
  doi: 10.1073/pnas.0504400102
– ident: e_1_3_5_218_2
  doi: 10.1016/S1097-2765(00)80412-8
– ident: e_1_3_5_107_2
  doi: 10.1523/JNEUROSCI.0203-11.2011
– ident: e_1_3_5_238_2
  doi: 10.1038/nprot.2012.067
– ident: e_1_3_5_232_2
  doi: 10.1523/JNEUROSCI.4090-04.2005
– ident: e_1_3_5_205_2
  doi: 10.1074/jbc.M111547200
– ident: e_1_3_5_158_2
  doi: 10.1111/j.1742-4658.2010.07827.x
– ident: e_1_3_5_92_2
  doi: 10.1016/j.bbadis.2006.12.006
– ident: e_1_3_5_40_2
  doi: 10.1177/104063870701900202
– ident: e_1_3_5_50_2
  doi: 10.1007/s00418-003-0524-5
– ident: e_1_3_5_140_2
  doi: 10.1016/S1097-2765(01)00265-9
– volume: 44
  start-page: 93
  year: 2006
  ident: e_1_3_5_13_2
  article-title: Variant CJD (vCJD) and bovine spongiform encephalopathy (BSE): 10 and 20 years on: Part 1
  publication-title: Folia Neuropathol.
  contributor:
    fullname: Bradley R
– ident: e_1_3_5_154_2
  doi: 10.1074/jbc.RA119.008822
– ident: e_1_3_5_146_2
  doi: 10.1091/mbc.10.11.3787
– ident: e_1_3_5_242_2
  doi: 10.1007/s004150070048
– ident: e_1_3_5_240_2
  doi: 10.1016/S0304-3940(02)01071-6
– ident: e_1_3_5_73_2
  doi: 10.1021/ar0301678
– ident: e_1_3_5_99_2
  doi: 10.1101/cshperspect.a024349
– ident: e_1_3_5_187_2
  doi: 10.1534/genetics.108.089458
– ident: e_1_3_5_86_2
  doi: 10.1016/0092-8674(93)90635-4
– ident: e_1_3_5_169_2
  doi: 10.1006/bbrc.1993.2466
– ident: e_1_3_5_57_2
  doi: 10.3201/eid2406.172007
– ident: e_1_3_5_150_2
  doi: 10.1016/j.tibs.2008.12.009
– ident: e_1_3_5_233_2
  doi: 10.1371/journal.pone.0015658
– ident: e_1_3_5_220_2
  doi: 10.1371/journal.pone.0087521
– ident: e_1_3_5_84_2
  doi: 10.1111/boc.201900045
– ident: e_1_3_5_172_2
  doi: 10.1016/j.celrep.2014.09.056
– ident: e_1_3_5_25_2
  doi: 10.1186/s12883-017-0886-2
– ident: e_1_3_5_237_2
  doi: 10.1074/jbc.RA118.006186
– ident: e_1_3_5_192_2
  doi: 10.1016/j.bbamcr.2010.03.005
– ident: e_1_3_5_177_2
  doi: 10.1038/nrm1247
– ident: e_1_3_5_81_2
  doi: 10.1038/nature07761
– ident: e_1_3_5_28_2
  doi: 10.1542/peds.2013-1396
– ident: e_1_3_5_183_2
  doi: 10.1073/pnas.0811571106
– ident: e_1_3_5_32_2
  doi: 10.1002/ana.21420
– ident: e_1_3_5_95_2
  doi: 10.1038/labinvest.3700676
– ident: e_1_3_5_215_2
  doi: 10.1016/j.jmb.2015.11.016
– ident: e_1_3_5_8_2
  doi: 10.1002/1531-8249(199908)46:2<224::AID-ANA12>3.0.CO;2-W
– ident: e_1_3_5_68_2
  doi: 10.1021/bi900108v
– ident: e_1_3_5_119_2
  doi: 10.1073/pnas.0502066102
– ident: e_1_3_5_252_2
  doi: 10.1126/scitranslmed.3006767
– ident: e_1_3_5_194_2
  doi: 10.1007/s002940000180
– ident: e_1_3_5_217_2
  doi: 10.1093/genetics/144.4.1375
– ident: e_1_3_5_166_2
  doi: 10.1016/S0092-8674(00)80928-9
– ident: e_1_3_5_219_2
  doi: 10.1128/MCB.20.23.8916-8922.2000
– ident: e_1_3_5_198_2
  doi: 10.1038/nsmb.3277
– ident: e_1_3_5_221_2
  doi: 10.1128/MCB.21.14.4656-4669.2001
– ident: e_1_3_5_168_2
  doi: 10.1016/S1357-2725(98)00091-0
– ident: e_1_3_5_76_2
  doi: 10.1038/cddis.2016.384
– ident: e_1_3_5_161_2
  doi: 10.1126/science.7754373
– ident: e_1_3_5_88_2
  doi: 10.1016/j.tibs.2006.01.002
– ident: e_1_3_5_101_2
  doi: 10.1371/journal.ppat.1002589
– ident: e_1_3_5_71_2
  doi: 10.1152/physrev.00006.2009
– volume: 41
  start-page: 318
  year: 2001
  ident: e_1_3_5_20_2
  article-title: A case of Gerstmann-Sträussler-Scheinker syndrome (GSS) with late onset: a haplotype analysis of Glu219Lys' polymorphism in PrP gene
  publication-title: Clin. Neurol.
  contributor:
    fullname: Takase KI
– ident: e_1_3_5_39_2
  doi: 10.14252/foodsafetyfscj.2016018
– ident: e_1_3_5_47_2
  doi: 10.1136/vr.129.11.233
– ident: e_1_3_5_207_2
  doi: 10.1371/journal.pone.0191490
– ident: e_1_3_5_256_2
  doi: 10.1016/S0006-8993(03)03045-2
– ident: e_1_3_5_144_2
  doi: 10.1101/gad.13.10.1211
– ident: e_1_3_5_189_2
  doi: 10.1093/genetics/156.2.559
– ident: e_1_3_5_63_2
  doi: 10.1111/j.1365-2990.2007.00868.x
– ident: e_1_3_5_227_2
  doi: 10.1038/emboj.2012.264
– ident: e_1_3_5_243_2
  doi: 10.1073/pnas.0711094105
– ident: e_1_3_5_79_2
  doi: 10.1038/22241
– ident: e_1_3_5_178_2
  doi: 10.1128/JB.176.24.7476-7483.1994
– ident: e_1_3_5_37_2
– ident: e_1_3_5_55_2
  doi: 10.1136/vr.130.17.365
– ident: e_1_3_5_31_2
  doi: 10.1097/WAD.0000000000000049
– ident: e_1_3_5_72_2
  doi: 10.1016/S0272-2712(02)00070-7
– volume: 26
  start-page: 577
  year: 1995
  ident: e_1_3_5_48_2
  article-title: Spongiform encephalopathy in another captive cheetah (Acinonyx jubatus): evidence for variation in susceptibility or incubation periods between species?
  publication-title: J. Zoo Wildl. Med.
  contributor:
    fullname: Kirkwood JK
– ident: e_1_3_5_211_2
  doi: 10.1091/mbc.e17-01-0070
– ident: e_1_3_5_60_2
  doi: 10.1016/B978-0-444-63945-5.00001-5
– volume: 36
  start-page: 63
  year: 2019
  ident: e_1_3_5_67_2
  article-title: Introduction to current progress in advanced research on prions
  publication-title: Curr. Issues Mol. Biol.
  contributor:
    fullname: Onodera T
– ident: e_1_3_5_152_2
  doi: 10.1128/MCB.13.2.1034
– ident: e_1_3_5_128_2
  doi: 10.1074/jbc.M110636200
– ident: e_1_3_5_113_2
  doi: 10.1016/S0076-6879(06)13017-7
– ident: e_1_3_5_254_2
  doi: 10.1097/01.jnen.0000218445.30535.6f
– ident: e_1_3_5_65_2
  doi: 10.1186/1743-422X-8-493
– ident: e_1_3_5_110_2
  doi: 10.1093/brain/awv006
– ident: e_1_3_5_38_2
  doi: 10.1046/j.1439-0442.2001.00312.x
– ident: e_1_3_5_106_2
  doi: 10.1113/jphysiol.2007.142448
– ident: e_1_3_5_49_2
  doi: 10.1136/vr.136.17.444
– ident: e_1_3_5_250_2
  doi: 10.1093/hmg/ddy152
– ident: e_1_3_5_246_2
  doi: 10.1038/s41551-019-0367-6
– ident: e_1_3_5_185_2
  doi: 10.1038/sj.emboj.7600985
– ident: e_1_3_5_135_2
  doi: 10.1038/mi.2012.105
– ident: e_1_3_5_139_2
  doi: 10.1073/pnas.0606480103
– ident: e_1_3_5_216_2
  doi: 10.1074/jbc.RA118.005980
– ident: e_1_3_5_186_2
  doi: 10.1128/MCB.22.11.3590-3598.2002
– ident: e_1_3_5_174_2
  doi: 10.1093/emboj/16.7.1501
– ident: e_1_3_5_212_2
  doi: 10.1074/jbc.274.22.15712
– ident: e_1_3_5_94_2
  doi: 10.1038/383685a0
– ident: e_1_3_5_54_2
  doi: 10.1136/vr.135.13.296
– ident: e_1_3_5_156_2
  doi: 10.1101/gad.12.24.3788
– ident: e_1_3_5_7_2
  doi: 10.1080/19336896.2016.1254858
– ident: e_1_3_5_42_2
  doi: 10.1146/annurev-animal-022114-111001
– ident: e_1_3_5_22_2
  doi: 10.1016/S0003-3995(03)00017-0
– ident: e_1_3_5_11_2
  doi: 10.1093/brain/awq234
– volume: 172
  start-page: 5
  year: 2006
  ident: e_1_3_5_255_2
  article-title: Molecular chaperones in health and disease
  publication-title: Handb. Exp. Pharmacol.
  contributor:
    fullname: Henningfield JE
– ident: e_1_3_5_90_2
  doi: 10.1371/journal.ppat.1006323
– ident: e_1_3_5_175_2
  doi: 10.1038/nature07195
– ident: e_1_3_5_241_2
  doi: 10.1006/nbdi.2001.0418
– ident: e_1_3_5_111_2
  doi: 10.1016/j.ejmech.2016.02.065
– ident: e_1_3_5_3_2
  doi: 10.1212/WNL.41.9.1390
– ident: e_1_3_5_153_2
  doi: 10.1128/MCB.23.17.6013-6026.2003
– ident: e_1_3_5_109_2
  doi: 10.1038/srep20526
– ident: e_1_3_5_89_2
  doi: 10.1371/journal.ppat.1002582
– ident: e_1_3_5_93_2
  doi: 10.1186/s12915-017-0375-5
– ident: e_1_3_5_235_2
  doi: 10.1038/srep44723
– ident: e_1_3_5_87_2
  doi: 10.1371/journal.ppat.1003537
– ident: e_1_3_5_108_2
  doi: 10.1038/nature03989
– ident: e_1_3_5_223_2
  doi: 10.1073/pnas.98.4.1442
– ident: e_1_3_5_234_2
  doi: 10.1074/jbc.M005543200
– ident: e_1_3_5_80_2
  doi: 10.4161/pri.22212
– ident: e_1_3_5_244_2
  doi: 10.1074/jbc.M611909200
– ident: e_1_3_5_46_2
  doi: 10.1093/infdis/115.4.387
– ident: e_1_3_5_91_2
  doi: 10.1128/JVI.74.12.5542-5547.2000
– ident: e_1_3_5_170_2
  doi: 10.1074/jbc.270.35.20298
– ident: e_1_3_5_12_2
  doi: 10.1126/science.1066838
– ident: e_1_3_5_182_2
  doi: 10.1534/genetics.111.137760
– ident: e_1_3_5_214_2
  doi: 10.1038/nrmicro.2015.4
– ident: e_1_3_5_27_2
  doi: 10.1002/1531-8249(200010)48:4<665::AID-ANA15>3.0.CO;2-D
– ident: e_1_3_5_34_2
  doi: 10.1098/rstb.2008.0068
– ident: e_1_3_5_82_2
  doi: 10.3389/fncel.2019.00339
– ident: e_1_3_5_196_2
  doi: 10.1007/s00294-019-01006-5
– ident: e_1_3_5_197_2
  doi: 10.1083/jcb.201201074
– ident: e_1_3_5_231_2
  doi: 10.1093/emboj/cdg537
– ident: e_1_3_5_29_2
  doi: 10.1056/NEJM199905273402104
– ident: e_1_3_5_58_2
  doi: 10.3390/pathogens6040067
– ident: e_1_3_5_104_2
  doi: 10.1038/nrn1007
– ident: e_1_3_5_133_2
  doi: 10.1128/MCB.23.21.7448-7459.2003
– ident: e_1_3_5_159_2
  doi: 10.1515/hsz-2018-0209
– ident: e_1_3_5_30_2
  doi: 10.1186/1471-2377-11-136
– ident: e_1_3_5_64_2
  doi: 10.2527/2005.8361455x
– ident: e_1_3_5_122_2
  doi: 10.1016/j.cub.2012.07.004
– ident: e_1_3_5_190_2
  doi: 10.1002/yea.1062
– ident: e_1_3_5_236_2
  doi: 10.1073/pnas.0710054104
– ident: e_1_3_5_143_2
  doi: 10.1073/pnas.1813352116
– ident: e_1_3_5_97_2
  doi: 10.1074/jbc.M405468200
– ident: e_1_3_5_23_2
  doi: 10.1093/bmb/66.1.213
– ident: e_1_3_5_66_2
  doi: 10.1099/vir.0.022103-0
– ident: e_1_3_5_83_2
  doi: 10.1523/JNEUROSCI.3307-17.2018
– ident: e_1_3_5_204_2
  doi: 10.1093/emboj/20.10.2435
– ident: e_1_3_5_44_2
  doi: 10.20506/rst.11.2.611
– ident: e_1_3_5_117_2
  doi: 10.1021/acschemneuro.9b00320
– ident: e_1_3_5_202_2
  doi: 10.1074/jbc.M606856200
– ident: e_1_3_5_130_2
  doi: 10.1074/jbc.M113.507491
– ident: e_1_3_5_136_2
  doi: 10.1073/pnas.1212484110
– ident: e_1_3_5_181_2
  doi: 10.1128/MMBR.00041-14
– ident: e_1_3_5_149_2
  doi: 10.1016/j.molcel.2017.12.003
– volume: 21
  start-page: 747
  year: 2015
  ident: e_1_3_5_184_2
  article-title: Yeast prion protein Ure2p: a useful model for human prion diseases
  publication-title: J. IMAB—Annu. Proc. Sci. Pap.
  contributor:
    fullname: Todorova TT
– ident: e_1_3_5_151_2
  doi: 10.1016/j.febslet.2015.10.010
– ident: e_1_3_5_123_2
  doi: 10.1074/jbc.274.43.30402
– ident: e_1_3_5_26_2
  doi: 10.1212/WNL.52.9.1757
– ident: e_1_3_5_163_2
  doi: 10.1006/scdb.1999.0320
– ident: e_1_3_5_10_2
  doi: 10.1001/archneur.63.6.876
– ident: e_1_3_5_230_2
  doi: 10.1128/JVI.70.7.4724-4728.1996
– ident: e_1_3_5_61_2
  doi: 10.1007/978-1-4614-0653-2_6
– ident: e_1_3_5_179_2
  doi: 10.1074/jbc.M307996200
– ident: e_1_3_5_35_2
  doi: 10.1016/0002-9343(59)90251-7
– ident: e_1_3_5_213_2
  doi: 10.1016/j.tibs.2008.09.010
– ident: e_1_3_5_157_2
  doi: 10.1111/j.1742-4658.2010.07828.x
– ident: e_1_3_5_125_2
  doi: 10.1128/MMBR.05018-11
– ident: e_1_3_5_129_2
  doi: 10.1002/j.1460-2075.1996.tb00624.x
– ident: e_1_3_5_193_2
  doi: 10.1128/MCB.19.12.8103
– ident: e_1_3_5_203_2
  doi: 10.1091/mbc.e07-02-0128
– ident: e_1_3_5_103_2
  doi: 10.1016/j.ejmech.2019.111753
– ident: e_1_3_5_162_2
  doi: 10.1007/978-1-61779-295-3_3
– ident: e_1_3_5_195_2
  doi: 10.1371/journal.pgen.1006431
– ident: e_1_3_5_258_2
  doi: 10.1038/sj.cdd.4401840
– ident: e_1_3_5_224_2
  doi: 10.1073/pnas.90.4.1315
– ident: e_1_3_5_36_2
  doi: 10.5694/j.1326-5377.1957.tb60287.x
– volume: 127
  start-page: 418
  year: 1990
  ident: e_1_3_5_56_2
  article-title: Spongiform encephalopathy in an arabian oryx (Oryx leucoryx) and a greater kudu (Tragelaphus strepsiceros)
  publication-title: Vet. Rec.
  contributor:
    fullname: Kirkwood JK
– ident: e_1_3_5_251_2
  doi: 10.1111/febs.14422
– ident: e_1_3_5_16_2
  doi: 10.1016/S0140-6736(06)68344-X
– ident: e_1_3_5_248_2
  doi: 10.1038/nrn1587
– ident: e_1_3_5_209_2
  doi: 10.1534/genetics.107.077982
– ident: e_1_3_5_201_2
  doi: 10.1074/jbc.M807369200
– ident: e_1_3_5_206_2
  doi: 10.3389/fmolb.2015.00010
– ident: e_1_3_5_112_2
  doi: 10.1007/978-94-007-2774-8_10
– ident: e_1_3_5_191_2
  doi: 10.1128/MCB.19.2.1325
– ident: e_1_3_5_52_2
  doi: 10.1093/bmb/66.1.199
– ident: e_1_3_5_78_2
  doi: 10.1111/j.1528-1157.1999.tb01583.x
– ident: e_1_3_5_19_2
  doi: 10.1093/brain/122.12.2375
– ident: e_1_3_5_102_2
  doi: 10.1038/s41593-018-0238-6
– ident: e_1_3_5_208_2
  doi: 10.1371/journal.pone.0001763
– ident: e_1_3_5_222_2
  doi: 10.15252/embj.201591245
– ident: e_1_3_5_4_2
  doi: 10.1007/s00439-005-0020-1
– ident: e_1_3_5_115_2
  doi: 10.1371/journal.pone.0003135
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Snippet Several neurodegenerative diseases of humans and animals are caused by the misfolded prion protein (PrP ), a self-propagating protein infectious agent that...
Several neurodegenerative diseases of humans and animals are caused by the misfolded prion protein (PrP Sc ), a self-propagating protein infectious agent that...
Several neurodegenerative diseases of humans and animals are caused by the misfolded prion protein (PrPSc), a self-propagating protein infectious agent that...
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SubjectTerms human
prions
protein chaperones
protein misfolding
Review
stress
yeast
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Title Understanding and exploiting interactions between cellular proteostasis pathways and infectious prion proteins for therapeutic benefit
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