Understanding and exploiting interactions between cellular proteostasis pathways and infectious prion proteins for therapeutic benefit

Several neurodegenerative diseases of humans and animals are caused by the misfolded prion protein (PrP ), a self-propagating protein infectious agent that aggregates into oligomeric, fibrillar structures and leads to cell death by incompletely understood mechanisms. Work in multiple biological mode...

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Published inOpen biology Vol. 10; no. 11; p. 200282
Main Authors Yakubu, Unekwu M, Catumbela, Celso S G, Morales, Rodrigo, Morano, Kevin A
Format Journal Article
LanguageEnglish
Published England The Royal Society 01.11.2020
Subjects
human
prions
protein chaperones
protein misfolding
Review
stress
yeast
stress
prions
protein chaperones
human
protein misfolding
yeast
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Summary:Several neurodegenerative diseases of humans and animals are caused by the misfolded prion protein (PrP ), a self-propagating protein infectious agent that aggregates into oligomeric, fibrillar structures and leads to cell death by incompletely understood mechanisms. Work in multiple biological model systems, from simple baker's yeast to transgenic mouse lines, as well as studies, has illuminated molecular and cellular modifiers of prion disease. In this review, we focus on intersections between PrP and the proteostasis network, including unfolded protein stress response pathways and roles played by the powerful regulators of protein folding known as protein chaperones. We close with analysis of promising therapeutic avenues for treatment enabled by these studies.
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Equal contributors.
ISSN:2046-2441
2046-2441
DOI:10.1098/rsob.200282