Metabolic Pathways in Immune Cell Activation and Quiescence

Studies of immune system metabolism (“immunometabolism”) segregate along two paths. The first investigates the effects of immune cells on organs that regulate whole-body metabolism, such as adipose tissue and liver. The second explores the role of metabolic pathways within immune cells and how this...

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Published in	Immunity (Cambridge, Mass.) Vol. 38; no. 4; pp. 633 - 643
Main Authors	Pearce, Erika L., Pearce, Edward J.
Format	Journal Article
Language	English
Published	United States Elsevier Inc 18.04.2013 Elsevier Limited
Subjects	Animals B-Lymphocytes - immunology Cell Survival Cellular Microenvironment - immunology Enzymes Gene expression Glucose Humans Immune system Immune System - cytology Immune System - metabolism Immunity - physiology Lymphocyte Activation Lymphocytes Metabolic Networks and Pathways - immunology Metabolism Metabolites Mitochondria Phosphates T-Lymphocytes - immunology
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Abstract	Studies of immune system metabolism (“immunometabolism”) segregate along two paths. The first investigates the effects of immune cells on organs that regulate whole-body metabolism, such as adipose tissue and liver. The second explores the role of metabolic pathways within immune cells and how this regulates immune response outcome. Distinct metabolic pathways diverge and converge at many levels, and, therefore, cells face choices as to how to achieve their metabolic goals. There is interest in fully understanding how and why immune cells commit to particular metabolic fates and in elucidating the immunologic consequences of reaching a metabolic endpoint by one pathway versus another. This is particularly intriguing, given that metabolic commitment is influenced not only by substrate availability but also by signaling pathways elicited by metabolites. Thus, metabolic choices in cells enforce fate and function, and this area will be the subject of this review.
AbstractList	Studies of immune system metabolism ("immunometabolism") segregate along two paths. The first investigates the effects of immune cells on organs that regulate whole-body metabolism, such as adipose tissue and liver. The second explores the role of metabolic pathways within immune cells and how this regulates immune response outcome. Distinct metabolic pathways diverge and converge at many levels, and, therefore, cells face choices as to how to achieve their metabolic goals. There is interest in fully understanding how and why immune cells commit to particular metabolic fates and in elucidating the immunologic consequences of reaching a metabolic endpoint by one pathway versus another. This is particularly intriguing, given that metabolic commitment is influenced not only by substrate availability but also by signaling pathways elicited by metabolites. Thus, metabolic choices in cells enforce fate and function, and this area will be the subject of this review.Studies of immune system metabolism ("immunometabolism") segregate along two paths. The first investigates the effects of immune cells on organs that regulate whole-body metabolism, such as adipose tissue and liver. The second explores the role of metabolic pathways within immune cells and how this regulates immune response outcome. Distinct metabolic pathways diverge and converge at many levels, and, therefore, cells face choices as to how to achieve their metabolic goals. There is interest in fully understanding how and why immune cells commit to particular metabolic fates and in elucidating the immunologic consequences of reaching a metabolic endpoint by one pathway versus another. This is particularly intriguing, given that metabolic commitment is influenced not only by substrate availability but also by signaling pathways elicited by metabolites. Thus, metabolic choices in cells enforce fate and function, and this area will be the subject of this review. Studies of immune system metabolism ("immunometabolism") segregate along two paths. The first investigates the effects of immune cells on organs that regulate whole-body metabolism, such as adipose tissue and liver. The second explores the role of metabolic pathways within immune cells and how this regulates immune response outcome. Distinct metabolic pathways diverge and converge at many levels, and, therefore, cells face choices as to how to achieve their metabolic goals. There is interest in fully understanding how and why immune cells commit to particular metabolic fates and in elucidating the immunologic consequences of reaching a metabolic endpoint by one pathway versus another. This is particularly intriguing, given that metabolic commitment is influenced not only by substrate availability but also by signaling pathways elicited by metabolites. Thus, metabolic choices in cells enforce fate and function, and this area will be the subject of this review. Studies of immune system metabolism (“immunometabolism”) segregate along two paths. The first investigates the effects of immune cells on organs that regulate whole body metabolism, such as adipose tissue and liver. The second explores the role of metabolic pathways within immune cells and how this regulates immune response outcome. Distinct metabolic pathways diverge and converge at many levels and cells therefore face choices in how to achieve their metabolic goals. There is interest in fully understanding how and why immune cells commit to particular metabolic fates, and in elucidating the immunologic consequences of reaching a metabolic endpoint by one pathway versus another. This is particularly intriguing since metabolic commitment is influenced not only by substrate availability, but also by signaling pathways elicited by metabolites. Thus metabolic choices in cells enforce fate and function and this area will be the subject of this review.
Author	Pearce, Erika L. Pearce, Edward J.
Author_xml	– sequence: 1 givenname: Erika L. surname: Pearce fullname: Pearce, Erika L. email: erikapearce@path.wustl.edu organization: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA – sequence: 2 givenname: Edward J. surname: Pearce fullname: Pearce, Edward J. email: edwardpearce@path.wustl.edu organization: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/23601682$$D View this record in MEDLINE/PubMed
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Snippet	Studies of immune system metabolism (“immunometabolism”) segregate along two paths. The first investigates the effects of immune cells on organs that regulate... Studies of immune system metabolism ("immunometabolism") segregate along two paths. The first investigates the effects of immune cells on organs that regulate...
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SubjectTerms	Animals B-Lymphocytes - immunology Cell Survival Cellular Microenvironment - immunology Enzymes Gene expression Glucose Humans Immune system Immune System - cytology Immune System - metabolism Immunity - physiology Lymphocyte Activation Lymphocytes Metabolic Networks and Pathways - immunology Metabolism Metabolites Mitochondria Phosphates T-Lymphocytes - immunology
Title	Metabolic Pathways in Immune Cell Activation and Quiescence
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