Metabolic Pathways in Immune Cell Activation and Quiescence

• Published in: Immunity (Cambridge, Mass.) Vol. 38; no. 4; pp. 633 - 643
• Main Authors: Pearce, Erika L., Pearce, Edward J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 18.04.2013; Elsevier Limited
• Subjects: Animals; B-Lymphocytes - immunology; Cell Survival; Cellular Microenvironment - immunology; Enzymes; Gene expression; Glucose; Humans; Immune system; Immune System - cytology; Immune System - metabolism; Immunity - physiology; Lymphocyte Activation; Lymphocytes; Metabolic Networks and Pathways - immunology; Metabolism; Metabolites; Mitochondria; Phosphates; T-Lymphocytes - immunology
• ISSN: 1074-7613; 1097-4180; 1097-4180
• DOI: 10.1016/j.immuni.2013.04.005

Studies of immune system metabolism (“immunometabolism”) segregate along two paths. The first investigates the effects of immune cells on organs that regulate whole-body metabolism, such as adipose tissue and liver. The second explores the role of metabolic pathways within immune cells and how this regulates immune response outcome. Distinct metabolic pathways diverge and converge at many levels, and, therefore, cells face choices as to how to achieve their metabolic goals. There is interest in fully understanding how and why immune cells commit to particular metabolic fates and in elucidating the immunologic consequences of reaching a metabolic endpoint by one pathway versus another. This is particularly intriguing, given that metabolic commitment is influenced not only by substrate availability but also by signaling pathways elicited by metabolites. Thus, metabolic choices in cells enforce fate and function, and this area will be the subject of this review.