Adverse events and association with age, sex and immunological parameters of Q fever vaccination in patients at risk for chronic Q fever in the Netherlands 2011

• Published in: Vaccine Vol. 32; no. 49; pp. 6622 - 6630
• Main Authors: Schoffelen, Teske, Wong, Albert, Rümke, Hans C, Netea, Mihai G, Timen, Aura, van Deuren, Marcel, Vermeer-de Bondt, Patricia E
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 20.11.2014; Elsevier; Elsevier Limited
• Subjects: Adolescent; Adult; Adverse events following immunization; Age; Age Factors; Aged; Aged, 80 and over; Allergy and Immunology; Antibiotics; Applied microbiology; Bacterial diseases; Bacteriology; Biological and medical sciences; Biomarkers; Confidence intervals; Coxiella burnetii; Diaries; Drug-Related Side Effects and Adverse Reactions - epidemiology; Female; Fever; Fundamental and applied biological sciences. Psychology; Health risk assessment; Human bacterial diseases; Humans; Immune response; Immunology; Infections; Infectious diseases; Interferon; Male; Medical sciences; Microbiology; Middle Aged; Miscellaneous; Netherlands - epidemiology; Pain; Q fever; Q Fever - immunology; Q Fever - prevention & control; Reading; Rickettsial diseases; Risk Factors; Safety; Sex Factors; Tropical bacterial diseases; Vaccination; Vaccination - adverse effects; Vaccination - methods; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Viral Vaccines - administration & dosage; Viral Vaccines - adverse effects; Young Adult; Netherlands; Europe; Western Europe; Victoria Australia; ST-locAE; Vaccination; Vac-locAE; systemic adverse event following vaccination; IFN-γ; adverse event with size or severity grade 3 or 4; local adverse event following skin test; local adverse event following vaccination; Safety; interferon-gamma; C. burnetii; serious adverse events; ST; Vac-systAE; Immune response; AE; systemic adverse event following skin test; adverse events; skin test; AE grade 3-4; ST-systAE; Q fever; SAE; AEFI; health council; HC; adverse events following immunization; Coxiella burnetii; Adverse events following immunization; Human; Immunization; Rickettsialosis; Toxicity; Sex; Vaccine; Infection; Rickettsiales; Chronic; Rickettsial infection; Bacteriosis; Bacteria; Rickettsieae; Rickettsiaceae; Age
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2014.09.061

Highlights • Q fever vaccination was safe, although rather reactogenic in this old-age risk-group. • Prior skin-testing led to local adverse events (AE) in 41% of potential vaccinees. • AEFI were more prevalent in women, younger age and those without immunosuppression. • Post-vaccination C. burnetii immunological parameters were associated with local AE. • The stringent requirement of pre-vaccination testing should be re-evaluated.