Comparison of Pandemrix and Arepanrix, two pH1N1 AS03-adjuvanted vaccines differentially associated with narcolepsy development

Highlights • The 4 main viral proteins found in Pandemrix and Arepanrix were HA, NA, NP and MA1. • HA and NA displayed charge heterogeneities notably involving glycans modifications. • Pandemrix was more deamidated and dioxidated suggesting that it was more degraded. • Interestingly, HA 146N was fou...

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Bibliographic Details
Published inBrain, behavior, and immunity Vol. 47; pp. 44 - 57
Main Authors Jacob, Louis, Leib, Ryan, Ollila, Hanna M, Bonvalet, Mélodie, Adams, Christopher M, Mignot, Emmanuel
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.07.2015
Subjects
2D-DIGE
Allergy and Immunology
Arepanrix
Gallus gallus
H1N1
Humans
Influenza A
Influenza Vaccines - adverse effects
Influenza Vaccines - metabolism
Influenza, Human - prevention & control
Mass Spectrometry
Narcolepsy
Narcolepsy - etiology
Pandemrix
Psychiatry
Vaccination - adverse effects
Vaccine
Viral Proteins - metabolism
NP
GlaxoSmithKline
2D-DIGE
hemagglutinin
MS
matrix protein 1
nucleoprotein
Vaccine
H1N1
NA
two dimensions difference gel electrophoresis
neuraminidase
polymerase 1
HA
mass spectrometry
Influenza A
Narcolepsy
Pandemrix
MA1
Arepanrix
GSK
PB1
Mass spectrometry
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Summary:Highlights • The 4 main viral proteins found in Pandemrix and Arepanrix were HA, NA, NP and MA1. • HA and NA displayed charge heterogeneities notably involving glycans modifications. • Pandemrix was more deamidated and dioxidated suggesting that it was more degraded. • Interestingly, HA 146N was found 10 times more deamidated in Arepanrix. • Chicken protein diversity was higher in Arepanrix.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2014.11.004