Treatment of negative symptoms of schizophrenia using repetitive transcranial magnetic stimulation in a double-blind, randomized controlled study

• Published in: Schizophrenia research Vol. 95; no. 1; pp. 151 - 157
• Main Authors: Prikryl, Radovan, Kasparek, Tomas, Skotakova, Simona, Ustohal, Libor, Kucerova, Hana, Ceskova, Eva
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.09.2007; Elsevier Science
• Subjects: Adult; Adult and adolescent clinical studies; Antipsychotic Agents - therapeutic use; Biological and medical sciences; Combined Modality Therapy; Double-Blind Method; Humans; Male; Medical sciences; Negative symptoms; Prefrontal Cortex - physiology; Psychiatric Status Rating Scales - statistics & numerical data; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; rTMS; Schizophrenia; Schizophrenia - diagnosis; Schizophrenia - drug therapy; Schizophrenia - therapy; Schizophrenic Psychology; Severity of Illness Index; Therapy; Transcranial Magnetic Stimulation; Treatment Outcome; Schizophrenia; Therapy; Negative symptoms; rTMS; Psychosis; Human; Treatment; Transcranial magnetic stimulation; Negative symptom; Magnetic stimulus; Double blind study
• ISSN: 0920-9964; 1573-2509
• DOI: 10.1016/j.schres.2007.06.019

Abstract Objective To verify whether high-frequency rTMS applied above the area of the left prefrontal cortex in 15 stimulation sessions with maximum stimulation intensity is able to modify negative symptoms of schizophrenia in a double-blind, randomized controlled study. Methods Twenty-two patients with schizophrenia stabilized on antipsychotic medication with prominent negative symptoms were included in the trial. They were divided into two groups: eleven were treated with effective rTMS and eleven with ineffective “sham” rTMS. The ineffectiveness of the sham rTMS was achieved through the stimulation coil position. Stimulation was applied to the left dorsolateral prefrontal cortex. The stimulation frequency was 10 Hz. Stimulation intensity was 110% of the motor threshold intensity. Each patient received 15 rTMS sessions on 15 consecutive working days. Each daily session consisted of 15 applications of 10-second duration and 30-second intervals between sequences. There were 1500 stimuli per session. Results During real rTMS treatment a statistically significant decrease of negative symptoms was found (approximately 29% reduction in the PANSS negative symptom subscale and 50% reduction in the SANS). No adverse events occurred during therapy except for a mild headaches. In sham rTMS treatment a decrease of negative symptoms was also identified, but to a lesser extent than in real rTMS (about 7% in negative subscale PANSS and 13% in SANS). The change in SANS achieved statistical significance. Mutual comparison revealed a greater decrease of negative symptoms in favor of real rTMS in contrast to sham rTMS. Conclusion The augmentation of rTMS enabled patients to experience a significant decrease in the severity of the negative symptoms. Our results support the therapeutic potential of rTMS at higher frequency for negative symptoms of schizophrenia.