PHS Guideline for Reducing Human Immunodeficiency Virus, Hepatitis B Virus, and Hepatitis C Virus Transmission Through Organ Transplantation

• Published in: Public health reports (1974) Vol. 128; no. 4; pp. 247 - 342
• Main Authors: Seem, Debbie L., Lee, Ingi, Umscheid, Craig A., Kuehnert, Matthew J.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA Association of Schools of Public Health 01.07.2013; SAGE Publications; SAGE PUBLICATIONS, INC
• Subjects: Adult; Biological and medical sciences; Blood; Blood donation; Child; Disease transmission; Disease Transmission, Infectious - prevention & control; Grading; Hepatitis; Hepatitis B; Hepatitis B - prevention & control; Hepatitis B - transmission; Hepatitis B virus; Hepatitis C; Hepatitis C - prevention & control; Hepatitis C - transmission; HIV; HIV Infections - prevention & control; HIV Infections - transmission; Human immunodeficiency virus; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infections; Infectious diseases; Medical sciences; Organ donation; Organ Transplantation - adverse effects; Organ Transplantation - standards; PHS Guideline; Predisposing factors; Public health; Systematic review; Tissue Donors; Transplantation; Transplantation of organs, tissues, etc; Transplants & implants; United States; United States Public Health Service; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral hepatitis; United States; Transmission; Orthohepadnavirus; Hepatic disease; Transplantation; Viral hepatitis B; Hepadnaviridae; Surgery; Graft; Hepatitis B virus; Viral hepatitis C; Immunopathology; Retroviridae; AIDS; Immune deficiency; Lentivirus; Recommendation; Infection; Virus; Treatment; Viral disease; Digestive diseases; Human immunodeficiency virus; Flaviviridae; Hepatitis C virus; Hepacivirus; Organ
• ISSN: 0033-3549; 1468-2877; 1468-2877
• DOI: 10.1177/003335491312800403

Seem et al examine data addressing 10 key questions within five major topic areas to evaluate the evidence on reducing transmission of HIV, hepatitis B virus, and hepatitis C virus through organ transplantation. They draw upon subject-matter experts to draft summaries related to these questions, as a preliminary scan of the literature showed that a systematic review would likely yield insufficient data. Recommendations related to the 10 key questions were based on a targeted systematic review of the best available evidence, with explicit links between the evidence and recommendations. To accomplish this review, they use a modified Grading of Recommendations, Assessment, Development, and Evaluation approach for evaluating quality of evidence and determining strength of recommendations.