Preservation of hippocampal volume throughout adulthood in healthy men and women

• Published in: Neurobiology of aging Vol. 26; no. 7; pp. 1093 - 1098
• Main Authors: Sullivan, Edith V., Marsh, Laura, Pfefferbaum, Adolf
• Format: Journal Article
• Language: English
• Published: London Elsevier Inc 01.07.2005; Elsevier Science
• Subjects: Adult; Adulthood; Aged; Aged, 80 and over; Aging - physiology; Biological and medical sciences; Development. Senescence. Regeneration. Transplantation; Female; Functional Laterality; Fundamental and applied biological sciences. Psychology; Hippocampal volume; Hippocampus - anatomy & histology; Humans; Image Processing, Computer-Assisted - methods; Magnetic Resonance Imaging - methods; Male; Middle Aged; MRI; Sex Factors; Statistics as Topic - methods; Temporal Lobe - anatomy & histology; Vertebrates: nervous system and sense organs; MRI; Hippocampal volume; Adulthood; Human; Volume; Central nervous system; Female; Nuclear magnetic resonance imaging; Age; Hippocampus; Encephalon
• ISSN: 0197-4580; 1558-1497
• DOI: 10.1016/j.neurobiolaging.2004.09.015

To address controversies regarding the effect of age on the hippocampus, volumes of hippocampus and a comparison structure, temporal cortex, were measured on magnetic resonance imaging (MRI) in 84 healthy men and 44 healthy women (20–85 years). Neither men nor women showed significant correlations between hippocampal volumes and age, despite significant age-related decline in temporal volumes. Absence of hippocampus age relationships endured when restricting analyses to older individuals (≥50 years) and considering menopause and hormone replacement therapy.