Allergic contact dermatitis from the vehicle components of topical pharmaceutical products

The local application of pharmaceutical products may induce skin adverse reactions, including allergic contact dermatitis. Indeed, pharmaceutical products are, in general, applied on diseased or inflamed skin, the barrier function of which is often incapacitated, leading to enhanced skin penetration...

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Bibliographic Details
Published inImmunology and allergy clinics of North America Vol. 34; no. 3; p. 663
Main Author Goossens, R An
Format Journal Article
LanguageEnglish
Published United States 01.08.2014
Subjects
Administration, Topical
Allergens - immunology
Dermatitis, Allergic Contact - diagnosis
Dermatitis, Allergic Contact - etiology
Humans
Pharmaceutical Preparations - administration & dosage
Pharmaceutical Vehicles - adverse effects
Pharmaceutical Vehicles - classification
Fragrances
Excipients
Preservatives
Allergic contact dermatitis
Iatrogenic
Topical pharmaceutical products
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Summary:The local application of pharmaceutical products may induce skin adverse reactions, including allergic contact dermatitis. Indeed, pharmaceutical products are, in general, applied on diseased or inflamed skin, the barrier function of which is often incapacitated, leading to enhanced skin penetration of the applied chemicals. Under these circumstances, even weak allergens are in such cases able to induce sensitization. The contact allergens in topical pharmaceutical products concern active principles and vehicle components, the latter of which are discussed in this article.
ISSN:1557-8607
DOI:10.1016/j.iac.2014.04.010