The role of chromium supplementation in cardiovascular risk factors: A comprehensive reviews of putative molecular mechanisms

• Published in: Heliyon Vol. 9; no. 9; p. e19826
• Main Authors: Gossa Al-Saadde, Dhiaa lattef, Haider, Ali Murtaza, Ali, Arsalan, Abdu Musad Saleh, Ebraheem, Turki Jalil, Abduladheem, Abdulelah, Furqan M., Romero-Parra, Rosario Mireya, Tayyib, Nahla A., Ramírez-Coronel, Andrés Alexis, Alkhayyat, Ameer S.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.09.2023; Elsevier
• Subjects: Cardiovascular diseases; Chromium; Hypertension; Inflammation; Oxidative stress; Review; Hypertension; Chromium; Oxidative stress; Inflammation; Cardiovascular diseases
• ISSN: 2405-8440; 2405-8440
• DOI: 10.1016/j.heliyon.2023.e19826

In the recent years, micronutrients play an important role in improving body health with preventing and treating of chronic diseases. Chromium is one of the vital minerals involved in the regulation of insulin action. According to abundant evidences this mineral seems to be an essential factor involved in the reduction of insulin resistance and decreasing the risk of type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVDs). Moreover, it has been proposed that Chromium supplementation affects mechanisms involved in blood pressure, lipid metabolism, inflammation, and oxidative stress. For instance, it may affect blood pressure through alteration of the renin-angiotensin system, as well as reducing the angiotensin-converting enzyme activity. Furthermore, Chromium supplementation might help reduce the coronary heart disease rates. This study aims to provide a comprehensive review regarding to the effects of Chromium supplementation on CVDs risk factors with an emphasis on possible molecular mechanisms.