Cancer stem cells: A contentious hypothesis now moving forward

Abstract Cancer stem cells are a progressive concept to account for the cell biological nature of cancer. Despite the controversies regarding the cancer stem cell model, it has the potential to provide a foundation for new innovative treatment targeting the roots of cancer. The last two years have w...

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Bibliographic Details
Published inCancer letters Vol. 344; no. 2; pp. 180 - 187
Main Authors O’Connor, Michael L, Xiang, Dongxi, Shigdar, Sarah, Macdonald, Joanna, Li, Yong, Wang, Tao, Pu, Chunwen, Wang, Zhidong, Qiao, Liang, Duan, Wei
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 28.03.2014
Elsevier Limited
Subjects
Animals
Aptamers
Biology
Breast cancer
Cancer stem cells
Cell division
Chemoresistance
Clinical trials
Clonal evolution
Drug Resistance, Neoplasm
Epigenetics
Experiments
Hematology, Oncology and Palliative Medicine
Humans
Hypotheses
Medical research
Metastasis
Neoplasms - drug therapy
Neoplasms - pathology
Neoplastic Stem Cells - pathology
Stem cells
Stemness
Studies
Tumors
Clonal evolution
Stemness
Cancer stem cells
Chemoresistance
Aptamers
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Summary:Abstract Cancer stem cells are a progressive concept to account for the cell biological nature of cancer. Despite the controversies regarding the cancer stem cell model, it has the potential to provide a foundation for new innovative treatment targeting the roots of cancer. The last two years have witnessed exceptional progress in cancer stem cell research, in particular on solid tumours, which holds promise for improved treatment outcomes. Here, we review recent advances in cancer stem cell research, discuss challenges in the field and explore future strategies and opportunities in cancer stem cell studies to overcome resistance to chemotherapy.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2013.11.012