Comparisons of short- and intermediate-term effects of pitavastatin versus atorvastatin on lipid profiles, fibrinolytic parameter, and endothelial function

Abstract We compared short- and intermediate-term effects on lipid profiles, fibrinolytic parameter, and endothelial function between pitavastatin and atorvastatin. Short-term improvement of endothelial function was superior with pitavastatin compared to atorvastatin therapy. Pitavastatin could be a...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of cardiology Vol. 125; no. 1; pp. 136 - 138
Main Authors Sakabe, Koichi, Fukuda, Nobuo, Fukuda, Yamato, Wakayama, Katsunori, Nada, Teru, Morishita, Satofumi, Shinohara, Hisanori, Tamura, Yoshiyuki
Format Journal Article
LanguageEnglish
Published Shannon Elsevier Ireland Ltd 28.03.2008
Elsevier Science
Subjects
Aged
Atorvastatin Calcium
Biological and medical sciences
Cardiology. Vascular system
Cardiovascular
Coronary Artery Disease - drug therapy
Coronary Artery Disease - physiopathology
Endothelial function
Endothelium, Vascular - drug effects
Female
Fibrinolysis - drug effects
Heptanoic Acids - pharmacology
Heptanoic Acids - therapeutic use
Humans
Hypercholesterolemia - drug therapy
Hypercholesterolemia - physiopathology
Hypolipidemic Agents - pharmacology
Lipid
Lipids - blood
Male
Medical sciences
Middle Aged
Pleiotropic effects
Prospective Studies
Pyrroles - pharmacology
Pyrroles - therapeutic use
Quinolines - pharmacology
Quinolines - therapeutic use
Statin
Time Factors
Vasodilation - drug effects
Statin
Endothelial function
Pleiotropic effects
Lipid
Short term
Lipids
Statin derivative
Phlebology
Profile
Pitavastatin
Atorvastatin
Parameter
Circulatory system
Cardiology
Comparative study
Fibrinolytic
Online AccessGet full text

Cover

More Information
Summary:Abstract We compared short- and intermediate-term effects on lipid profiles, fibrinolytic parameter, and endothelial function between pitavastatin and atorvastatin. Short-term improvement of endothelial function was superior with pitavastatin compared to atorvastatin therapy. Pitavastatin could be a potentially better therapeutic choice for lipid-lowering and early alterations in endothelial function. Our study provides an important basis on which further trials involving larger numbers of patients may be studied prospectively.
Bibliography:SourceType-Other Sources-1
ObjectType-Article-2
ObjectType-Feature-1
ObjectType-Correspondence-3
content type line 66
ObjectType-News-4
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2007.01.040