Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape From Combination Monoclonal Antibody Treatment in a Person With HIV

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escape from combination monoclonal antibody treatment is rarely reported. We describe an immunocompromised individual with human immunodeficiency virus and persistent SARS-CoV-2 infection in whom substantial SARS-CoV-2 evolution o...

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Published inOpen forum infectious diseases Vol. 10; no. 2; p. ofad054
Main Authors Khosravi, Dara, Soloff, Hannah, Langsjoen, Rose M, Bombin, Andrei, Kelley, Colleen F, Ray, Susan M, Gunthel, Clifford J, Zanoni, Brian C, Nguyen, Phuong-Vi, Waggoner, Jesse J, Wang, Yun F, Cantos, Valeria D, Piantadosi, Anne
Format Journal Article
LanguageEnglish
Published US Oxford University Press 01.02.2023
Subjects
Brief Report
SARS-CoV-2
immunocompromised
HIV
monoclonal antibody
virus evolution
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Summary:Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escape from combination monoclonal antibody treatment is rarely reported. We describe an immunocompromised individual with human immunodeficiency virus and persistent SARS-CoV-2 infection in whom substantial SARS-CoV-2 evolution occurred, including the emergence of 2 mutations associated with escape from the monoclonal antibody cocktail received.
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Potential conflicts of interest. C. F. K. has received institutional research funding from Gilead Sciences, ViiV, Moderna, Novavax, and Humanigen. All other authors report no potential conflicts.
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofad054