RIT2 polymorphism is associated with Parkinson's disease in a Han Chinese population

• Published in: Neurobiology of aging Vol. 36; no. 3; pp. 1603.e15 - 1603.e17
• Main Authors: Nie, Kun, Feng, Shu-jun, Tang, Hong-mei, Ma, Gui-xian, Gan, Rong, Zhao, Xin, Zhao, Jie-hao, Wang, Li-min, Huang, Zhi-heng, Huang, Jing, Gao, Liang, Zhang, You-wen, Zhu, Rui-ming, Duan, Zhen-peng, Zhang, Yu-hu, Wang, Li-juan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2015
• Subjects: Aged; Alleles; Asian Continental Ancestry Group - genetics; Female; Genetic Predisposition to Disease - genetics; Genome-Wide Association Study; Genotype; Heterozygote; Humans; Internal Medicine; Logistic Models; Male; Middle Aged; Monomeric GTP-Binding Proteins - genetics; Neurology; Parkinson Disease - genetics; Parkinson's disease; Polymorphism; Polymorphism, Genetic - genetics; Risk; RIT2; rs12456492; Variant; Variant; rs12456492; RIT2; Parkinson's disease; Polymorphism
• ISSN: 0197-4580; 1558-1497
• DOI: 10.1016/j.neurobiolaging.2014.10.013

Abstract Recently, a meta-analysis including 5 large genome-wide association studies has identified rs12456492 variant of RIT2 gene as a novel risk locus for Parkinson's disease (PD) in Caucasian populations. However, the association between RIT2 polymorphism and PD risk has not been positively replicated in Asian population yet. We detected the genotypes of rs12456492 in 524 PD patients and 521 control subjects from a Han Chinese population. The allele and genotype distribution of rs12456492 variant were significantly different between PD patients and controls (allele p  = 0.001, genotype p  = 0.002). Logistic regression analysis showed that the G-carrying genotype (AG + GG) individuals exhibited a nearly 1.4-fold increased risk for PD compared with the AA genotype carriers (OR = 1.390; 95% confidence interval = 1.079–1.791; p  = 0.011). Our data support that the carriage of G allele of rs12456492 variant of RIT2 gene significantly increases the risk for PD in Han Chinese population, suggesting a potential role of RIT2 in the etiology of PD.