CORNEXISTIN: A NEW FUNGAL METABOLITE WITH HERBICIDAL ACTIVITY

Cornexistin, a new compound demonstrating promising herbicidal activity, was purified from the culture filtrate of a newly-isolated fungus identified as Paecilomyces variotii SANK 21086. The compound was extracted with organic solvents from the culture filtrate, purified using column chromatography...

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Published inJournal of antibiotics Vol. 44; no. 10; pp. 1065 - 1072
Main Authors NAKAJIMA, MUTSUO, ITOI, KAZUKO, TAKAMATSU, YASUYUKI, SATO, SADAO, FURUKAWA, YOUJI, FURUYA, KOUHEI, HONMA, TOYOKUNI, KADOTANI, JUNJI, KOZASA, MAKOTO, HANEISHI, TATSUO
Format Journal Article
LanguageEnglish
Published Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 01.10.1991
Japan Antibiotics Research Association
Subjects
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Biological and medical sciences
Chemotherapic agents
Chromatography
Crystallization
Fermentation
Fundamental and applied biological sciences. Psychology
Furans - chemistry
Furans - isolation & purification
Furans - pharmacology
Furans - toxicity
Herbicides - chemistry
Herbicides - isolation & purification
Herbicides - pharmacology
Herbicides - toxicity
Hydrogen-Ion Concentration
Kinetics
Microbiology
Molecular Structure
Paecilomyces - chemistry
Paecilomyces - isolation & purification
Paecilomyces - metabolism
Plants - drug effects
Spectrophotometry, Infrared
X-Ray Diffraction
Fungi
Paecilomyces varioti
Isolation
Biosynthesis
Fungi Imperfecti
Fermentation
Biological activity
Herbicide
Physicochemical properties
Thallophyta
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Summary:Cornexistin, a new compound demonstrating promising herbicidal activity, was purified from the culture filtrate of a newly-isolated fungus identified as Paecilomyces variotii SANK 21086. The compound was extracted with organic solvents from the culture filtrate, purified using column chromatography on Sephadex LH-20 and finally crystallized from methylene chloride. Following analysis of its physico-chemical properties it was identified to be a new compound belonging to the nonadride group. Chemical structure elucidation was conducted by analyses of various spectral data and the structure was finally confirmed by means of X-ray crystallographic analysis. Based on its herbicidal characteristics cornexistin may be classified as a postemergence herbicide active against certain young annual and perennial monocotyledonous and dicotyledonous plants with selective protection for corn.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.44.1065