Water-Soluble Metalated Covalent Organic Nanobelts with Improved Bioavailability for Protein Transportation

An available pathway to prepare the ionized covalent organic nanosheets (iCONs) has been proposed by a metal-assisted aqueous-phase exfoliation route from covalent organic frameworks. The soluble and belt-shaped iCONs could immobilize a large quantity of proteins (2.73 mg/mg, BSA/iCONs) and hence se...

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Published inScientific reports Vol. 8; no. 1; pp. 5529 - 8
Main Authors Kong, Weifu, Wan, Jiaxun, Namuangruk, Supawadee, Guo, Jia, Wang, Changchun
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 03.04.2018
Nature Publishing Group
Subjects
119/118
14/35
639/301/923/1028
639/925/357/1018
Bioavailability
Cancer
Clathrin
Coated pits
Endocytosis
Humanities and Social Sciences
multidisciplinary
Protein transport
Science
Science (multidisciplinary)
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Summary:An available pathway to prepare the ionized covalent organic nanosheets (iCONs) has been proposed by a metal-assisted aqueous-phase exfoliation route from covalent organic frameworks. The soluble and belt-shaped iCONs could immobilize a large quantity of proteins (2.73 mg/mg, BSA/iCONs) and hence serve as transporters to enhance the protein uptake by cancer cells. Meanwhile, their energy-dependent endocytosis pathway via clathrin-coated pits has been proved as well.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-23744-1