Enabling a systems biology approach to immunology: focus on innate immunity

• Published in: Trends in immunology Vol. 30; no. 6; pp. 249 - 262
• Main Authors: Gardy, Jennifer L., Lynn, David J., Brinkman, Fiona S.L., Hancock, Robert E.W.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2009; Elsevier Limited
• Subjects: Allergy and Immunology; Animals; Bacterial infections; Biology; Computer Simulation; Databases as Topic; Gene expression; Gene Expression Profiling; Genetic engineering; Genetic Predisposition to Disease; Genomes; Genomics; Genomics - trends; Humans; Image Processing, Computer-Assisted; Immune system; Immunity, Innate; Kinases; Ligands; Medical Informatics Applications; MicroRNAs; MicroRNAs - immunology; Polymorphism, Genetic; Proteins; Proteomics - trends; Signal transduction; Signal Transduction - immunology; Systems Biology - trends
• ISSN: 1471-4906; 1471-4981; 1471-4981
• DOI: 10.1016/j.it.2009.03.009

Immunity is not simply the product of a series of discrete linear signalling pathways; rather it is comprised of a complex set of integrated responses arising from a dynamic network of thousands of molecules subject to multiple influences. Its behaviour often cannot be explained or predicted solely by examining its components. Here, we review recently developed resources for the systems-level investigation of immunity. Although innate immunity is emphasized here, its considerable overlap with adaptive immunity makes many of these resources relevant to both arms of the immune response. We discuss recent studies implementing these approaches and illustrate the potential of systems biology to generate novel insights into the complexities of innate immunity.