The Effects of Four Compounds That Act on the Dopaminergic and Serotonergic Systems on Working Memory in Animal Studies; A Literature Review

The dopaminergic and serotonergic systems are two of the most important neuronal pathways in the human brain. Almost all psychotropic medications impact at least one neurotransmitter system. As a result, investigating how they affect memory could yield valuable insights into potential therapeutic ap...

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Published inBrain sciences Vol. 13; no. 4; p. 546
Main Authors Grosu, Ștefania-Alexandra, Chirilă, Marinela, Rad, Florina, Enache, Andreea, Handra, Claudia-Mariana, Ghiță, Isabel
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 25.03.2023
MDPI
Subjects
Animal cognition
Brain
Bromocriptine
Dopamine
Dopamine D2 receptors
Fluoxetine
haloperidol
Health aspects
Human subjects
Ketanserin
Literature reviews
Memory
Neurons
Neurotransmitters
Pharmaceuticals
Psychotropic drugs
Schizophrenia
Serotonin
Short term memory
Systematic Review
Therapeutic applications
working memory
United Kingdom
Romania
haloperidol
fluoxetine
bromocriptine
working memory
ketanserin
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Summary:The dopaminergic and serotonergic systems are two of the most important neuronal pathways in the human brain. Almost all psychotropic medications impact at least one neurotransmitter system. As a result, investigating how they affect memory could yield valuable insights into potential therapeutic applications or unanticipated side effects. The aim of this literature review was to collect literature data from animal studies regarding the effects on memory of four drugs known to act on the serotonergic and dopaminergic systems. The studies included in this review were identified in the PubMed database using selection criteria from the PRISMA protocol. We analyzed 29 articles investigating one of four different dopaminergic or serotonergic compounds. Studies conducted on bromocriptine have shown that stimulating D2 receptors may enhance working memory in rodents, whereas inhibiting these receptors could have the opposite effect, reducing working memory performance. The effects of serotonin on working memory are not clearly established as studies on fluoxetine and ketanserin have yielded conflicting results. Further studies with better-designed methodologies are necessary to explore the impact of compounds that affect both the dopaminergic and serotonergic systems on working memory.
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These authors contributed equally to this work.
ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci13040546