Proteomic profiling of epileptogenesis in a rat model: Focus on inflammation

• Published in: Brain, behavior, and immunity Vol. 53; pp. 138 - 158
• Main Authors: Walker, Andreas, Russmann, Vera, Deeg, Cornelia A, von Toerne, Christine, Kleinwort, Kristina J.H, Szober, Christoph, Rettenbeck, Maruja L, von Rüden, Eva-Lotta, Goc, Joanna, Ongerth, Tanja, Boes, Katharina, Salvamoser, Josephine D, Vezzani, Annamaria, Hauck, Stefanie M, Potschka, Heidrun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.03.2016
• Subjects: Allergy and Immunology; Animals; Biomarkers - metabolism; Cerebral Cortex - metabolism; Cytokines - metabolism; Disease Models, Animal; Epilepsy; Epilepsy - etiology; Epilepsy - genetics; Epilepsy - metabolism; Female; Gene Expression Profiling; Heat shock proteins; Hippocampus - metabolism; Inflammation; Inflammation - genetics; Inflammation - metabolism; Innate immunity; Mass spectrometry; Parahippocampal Gyrus - metabolism; Proteome - metabolism; Proteomics; Proteomics - methods; Psychiatry; Purinoceptors; Rats; Rats, Sprague-Dawley; Receptors, Purinergic - metabolism; Signal Transduction; Status epilepticus; Tandem Mass Spectrometry - methods; Toll-like receptors; Toll-Like Receptors - metabolism; Epilepsy; Proteomics; Toll-like receptors; Heat shock proteins; Innate immunity; Inflammation; Purinoceptors; Status epilepticus; Mass spectrometry
• ISSN: 0889-1591; 1090-2139
• DOI: 10.1016/j.bbi.2015.12.007

Highlights • Expression patterns were analyzed in key brain regions during epileptogenesis. • The analysis revealed enrichment of multiple inflammatory signaling pathways. • Toll-like receptor (TLR) ligands and signaling factors were intensely regulated. • A delayed induction of purinoceptors P2X7 and P2Y12 was observed. • Data provide valuable information for the selection of novel biomarkers and targets.