Lsm7 phase-separated condensates trigger stress granule formation

• Published in: Nature communications Vol. 13; no. 1; p. 3701
• Main Authors: Lindström, Michelle, Chen, Lihua, Jiang, Shan, Zhang, Dan, Gao, Yuan, Zheng, Ju, Hao, Xinxin, Yang, Xiaoxue, Kabbinale, Arpitha, Thoma, Johannes, Metzger, Lisa C, Zhang, Deyuan Y, Zhu, Xuefeng, Liu, Huisheng, Gustafsson, Claes M, Burmann, Björn M, Winderickx, Joris, Sunnerhagen, Per, Liu, Beidong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group 28.06.2022; Nature Publishing Group UK; Nature Portfolio
• Subjects: Age; Age related diseases; Biology; Condensates; Genomes; Glucose; Granular materials; Hydrophobicity; Liquid phases; Localization; Organelles; Phase separation; Protein expression; Protein seeding; Proteins; Yeasts

Abstract Stress granules (SGs) are non-membranous organelles facilitating stress responses and linking the pathology of age-related diseases. In a genome-wide imaging-based phenomic screen, we identify Pab1 co-localizing proteins under 2-deoxy-D-glucose (2-DG) induced stress in Saccharomyces cerevis...