Difference in the craniocaudal gradient of the maximum pixel value change rate between chronic obstructive pulmonary disease patients and normal subjects using sub-mGy dynamic chest radiography with a flat panel detector system

• Published in: European journal of radiology Vol. 92; pp. 37 - 44
• Main Authors: Yamada, Yoshitake, Ueyama, Masako, Abe, Takehiko, Araki, Tetsuro, Abe, Takayuki, Nishino, Mizuki, Jinzaki, Masahiro, Hatabu, Hiroto, Kudoh, Shoji
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.07.2017
• Subjects: Aged, 80 and over; Exhalation; Female; Humans; Lung; Male; Posture; Prospective Studies; Pulmonary Disease, Chronic Obstructive - diagnostic imaging; Radiography - methods; Radiology; Respiration; Thorax; Ventilation; X-ray; GOLD; MRI; Lung; Thorax; VC; FIR; CT; SD; FEV; MPCR; Ventilation; FPD; X-ray; Respiration; BMI; COPD; magnetic resonance imaging; global initiative for chronic obstructive pulmonary disease; finite impulse response; vital capacity; maximum pixel value change rate; computed tomography; body mass index; forced expiratory volume; flat panel detector; chronic obstructive pulmonary disease; standard deviation
• ISSN: 0720-048X; 1872-7727; 1872-7727
• DOI: 10.1016/j.ejrad.2017.04.016

•Dynamic chest radiography is feasible for the evaluation of pulmonary ventilation.•It could detect physiological differences between normal subjects and COPD patients.•Craniocaudal gradients of MPCR were lower in COPD patients than normal subjects. To compare the craniocaudal gradients of the maximum pixel value change rate (MPCR) during tidal breathing between chronic obstructive pulmonary disease (COPD) patients and normal subjects using dynamic chest radiography. This prospective study was approved by the institutional review board and all participants provided written informed consent. Forty-three COPD patients (mean age, 71.6±8.7 years) and 47 normal subjects (non-smoker healthy volunteers) (mean age, 54.8±9.8 years) underwent sequential chest radiographs during tidal breathing in a standing position using dynamic chest radiography with a flat panel detector system. We evaluated the craniocaudal gradient of MPCR. The results were analyzed using an unpaired t-test and the Tukey–Kramer method. The craniocaudal gradients of MPCR in COPD patients were significantly lower than those in normal subjects (right inspiratory phase, 75.5±48.1 vs. 108.9±42.0s−1cm−1, P<0.001; right expiratory phase, 66.4±40.6 vs. 89.8±31.6s−1cm−1, P=0.003; left inspiratory phase, 75.5±48.2 vs. 108.2±47.2s−1cm−1, P=0.002; left expiratory phase, 60.9±38.2 vs. 84.3±29.5s−1cm−1, P=0.002). No significant differences in height, weight, or BMI were observed between COPD and normal groups. In the sub-analysis, the gradients in severe COPD patients (global initiative for chronic obstructive lung disease [GOLD] 3 or 4, n=26) were significantly lower than those in mild COPD patients (GOLD 1 or 2, n=17) for both right and left inspiratory/expiratory phases (all P≤0.005). A decrease of the craniocaudal gradient of MPCR was observed in COPD patients. The craniocaudal gradient was lower in severe COPD patients than in mild COPD patients.