Role for the Unfolded Protein Response in Heart Disease and Cardiac Arrhythmias

The unfolded protein response (UPR) has been extensively investigated in neurological diseases and diabetes, while its function in heart disease is less well understood. Activated UPR participates in multiple cardiac conditions and can either protect or impair heart function. Recently, the UPR has b...

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Bibliographic Details
Published inInternational Journal of Molecular Sciences Vol. 17; no. 1; p. 52
Main Authors Liu, Man, Dudley, Jr, Samuel C
Format Journal Article Book Review
LanguageEnglish
Published Switzerland MDPI AG 01.01.2016
MDPI
Subjects
Animals
Arrhythmias, Cardiac - drug therapy
Arrhythmias, Cardiac - genetics
Arrhythmias, Cardiac - metabolism
Arrhythmias, Cardiac - pathology
ATF6α
Cardiac arrhythmia
cardiac ion channels
Cardiovascular disease
Grp78
Heart
Heart Diseases - drug therapy
Heart Diseases - genetics
Heart Diseases - metabolism
Heart Diseases - pathology
Humans
IRE1
ischemia
Molecular Targeted Therapy
PERK
Protein folding
Review
Unfolded Protein Response - drug effects
Grp78
PERK
ATF6α
IRE1
cardiac ion channels
ischemia
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Summary:The unfolded protein response (UPR) has been extensively investigated in neurological diseases and diabetes, while its function in heart disease is less well understood. Activated UPR participates in multiple cardiac conditions and can either protect or impair heart function. Recently, the UPR has been found to play a role in arrhythmogenesis during human heart failure by affecting cardiac ion channels expression, and blocking UPR has an antiarrhythmic effect. This review will discuss the rationale for and challenges to targeting UPR in heart disease for treatment of arrhythmias.
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms17010052