The Association among Hypothalamic Subnits, Gonadotropic and Sex Hormone Plasmas Levels in Alzheimer's Disease

• Published in: Brain sciences Vol. 14; no. 3; p. 276
• Main Authors: Ofori, Edward, Solis, Anamaria, Punjani, Nahid, On Behalf Of The Alzheimer's Disease Neuroimaging Initiative
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.03.2024; MDPI
• Subjects: Alzheimer's disease; Biomarkers; Brain; Brief Report; Cognitive ability; cognitive status; Cortex (entorhinal); Development and progression; Diagnosis; Follicle-stimulating hormone; Gender differences; Glycoproteins; gonadotropic hormones; Hormones; hypothalamic–pituitary–gonadal axis; Hypothalamus; Luteinizing hormone; Magnetic resonance imaging; neurodegeneration; Neurodegenerative diseases; Pharmaceutical industry; Pituitary; Pituitary (anterior); Pituitary hormones; Plasma levels; Progesterone; Sex differences; Sex hormones; Testosterone; United States; hypothalamic–pituitary–gonadal axis; cognitive status; gonadotropic hormones; neuroendocrine dysfunction; Alzheimer’s disease; sex hormones; neurodegeneration; hypothalamic volume
• ISSN: 2076-3425; 2076-3425
• DOI: 10.3390/brainsci14030276

This study investigates the sex-specific role of the Hypothalamic-Pituitary-Gonadal axis in Alzheimer's disease progression, utilizing ADNI1 data for 493 individuals, analyzing plasma levels of gonadotropic and sex hormones, and examining neurodegeneration-related brain structures. We assessed plasma levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), progesterone (P4), and testosterone (T), along with volumetric measures of the hippocampus, entorhinal cortex, and hypothalamic subunits, to explore their correlation with Alzheimer's disease markers across different cognitive statuses and sexes. Significant cognitive status effects were observed for all volumetric measures, with a distinct sex-by-cognitive status interaction for hypothalamic volume, indicating a decrease in males but not in females across cognitive impairment stages. Regression analyses showed specific hypothalamic subunit volume related to hormone levels, accounting for up to approximately 40% of the variance ( < 0.05). The findings highlight sex differences in neurodegeneration and hormonal regulation, suggesting potential for personalized treatments and advancing the understanding of Alzheimer's disease etiology.