Ovalbumin Epitope SIINFEKL Self-Assembles into a Supramolecular Hydrogel

Here we show that the well-known ovalbumin epitope SIINFEKL that is routinely used to stimulate ovalbumin-specific T cells and to test new vaccine adjuvants can form a stable hydrogel. We investigate properties of this hydrogel by a range of spectroscopic and imaging techniques demonstrating that th...

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Published inScientific reports Vol. 9; no. 1; p. 2696
Main Authors Kamalov, Meder, Kählig, Hanspeter, Rentenberger, Christian, Müllner, Alexander R.M., Peterlik, Herwig, Becker, Christian F. W.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 25.02.2019
Nature Publishing Group
Subjects
101/6
14/28
140/131
631/250/590/2030
639/638/92/611
Adjuvants
Epitopes
Humanities and Social Sciences
Hydrogels
Immune response
Lymphocytes T
multidisciplinary
Ovalbumin
Peptides
Science
Science (multidisciplinary)
Self-assembly
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Summary:Here we show that the well-known ovalbumin epitope SIINFEKL that is routinely used to stimulate ovalbumin-specific T cells and to test new vaccine adjuvants can form a stable hydrogel. We investigate properties of this hydrogel by a range of spectroscopic and imaging techniques demonstrating that the hydrogel is stabilized by self-assembly of the peptide into nanofibres via stacking of β-sheets. As peptide hydrogels are known to stimulate an immune response as adjuvants, the immunoactive properties of the SIINFEKL peptide may also originate from its propensity to self-assemble into a hydrogel. This finding requires a re-evaluation of this epitope in adjuvant testing.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-39148-8