Patterns of cervical coinfection with multiple human papilloma virus types in a screening population in Denmark

• Published in: Vaccine Vol. 31; no. 12; pp. 1604 - 1609
• Main Authors: Goldman, Bryan, Rebolj, Matejka, Rygaard, Carsten, Preisler, Sarah, Ejegod, Ditte Møller, Lynge, Elsebeth, Bonde, Jesper
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 15.03.2013; Elsevier; Elsevier Limited
• Subjects: Adult; Aged; Allergy and Immunology; Applied microbiology; Biological and medical sciences; Cervical cancer; Cervix Uteri - virology; Coinfection; Coinfection - epidemiology; Coinfection - virology; Computer Simulation; Denmark; Denmark - epidemiology; DNA, Viral - analysis; Female; Fundamental and applied biological sciences. Psychology; Genotype; Genotypes; HPV vaccination; Human papillomavirus; Humans; Immunization; Mass Screening; Medical sciences; Microbiology; Middle Aged; Miscellaneous; Papillomaviridae - classification; Papillomavirus Infections - epidemiology; Papillomavirus Infections - virology; Papillomavirus Vaccines - administration & dosage; Prevalence; Risk Factors; Tumors; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Virology; Young Adult; Denmark; Scandinavia; Europe; Denmark; Human papillomavirus; Coinfection; HPV vaccination; Cervical cancer; Human; Mixed infection; Vaccination; Papovaviridae; Malignant tumor; Female genital diseases; Papillomavirus; Virus; Papilloma; Benign neoplasm; Uterine cervix diseases; Cancer
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2012.12.084

Highlights ► Human papillomavirus (HPV) genotypes may not be independent of each other. ► We assessed 35 HPV genotypes on cervical samples from 5014 Danish women. ► We propose a simulation-based method for analysis of HPV coinfection patterns. ► Associations between some HPV types not driven only by common risk factors. ► No evidence that eradication of vaccine types may lead to increase in other types.