Clinical Management of Ebola Virus Disease in the United States and Europe

• Published in: The New England journal of medicine Vol. 374; no. 7; pp. 636 - 646
• Main Authors: Uyeki, Timothy M, Mehta, Aneesh K, Davey, Richard T, Liddell, Allison M, Wolf, Timo, Vetter, Pauline, Schmiedel, Stefan, Grünewald, Thomas, Jacobs, Michael, Arribas, Jose R, Evans, Laura, Hewlett, Angela L, Brantsaeter, Arne B, Ippolito, Giuseppe, Rapp, Christophe, Hoepelman, Andy I.M, Gutman, Julie
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 18.02.2016
• Subjects: Adult; Aged; Anti-Bacterial Agents - therapeutic use; Antibiotics; Anuria; Combined Modality Therapy; Critical Care; Diarrhea; Dietary supplements; Disease control; Disease management; Ebola virus; Ebolavirus; Ebolavirus - genetics; Ebolavirus - isolation & purification; Electrolytes - therapeutic use; Europe; Fatigue; Female; Fever; Fluid Therapy; Hemorrhagic Fever, Ebola - complications; Hemorrhagic Fever, Ebola - mortality; Hemorrhagic Fever, Ebola - therapy; Humans; Hypocalcemia; Hypokalemia; Hypomagnesemia; Hyponatremia; Hypoxemia; Infections; Intravenous administration; Kidneys; Length of Stay; Male; Mechanical ventilation; Middle Aged; Mortality; Renal failure; Respiration, Artificial; Ribonucleic acid; RNA; RNA, Viral - blood; Severity of Illness Index; Transaminases - blood; United States; Viral Load; Viremia; United States; Europe; United States > US; West Africa
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJMoa1504874

Since the beginning of the current Ebola epidemic, several patients with Ebola virus disease have been cared for in the United States and Europe. In this report, the clinical course and care of these 27 patients are described. The Ebola virus disease (EVD) epidemic in West Africa had resulted in more than 28,600 reported cases and more than 11,300 deaths through December 2015; mortality reported for patients with EVD cared for in Ebola treatment units in West Africa has ranged from 37 to 74%. 1 – 5 The provision of clinical care to patients with EVD in Ebola treatment units in West Africa has involved the need to balance many challenges, such as overwhelming numbers of severely ill patients, limited medical and nonmedical supplies, insufficient numbers of caregivers and resources, and hot and humid working conditions that limit the time . . .