Phthalimide-N-oxyl (PINO) Radical, a Powerful Catalytic Agent: Its Generation and Versatility Towards Various Organic Substrates

• Published in: Catalysis reviews. Science and engineering Vol. 51; no. 2; pp. 218 - 292
• Main Author: Coseri, Sergiu
• Format: Journal Article
• Language: English
• Published: Colchester Taylor & Francis Group, LLC 01.04.2009; Taylor & Francis
• Subjects: Catalysis; Catalysts; Chemistry; Chemists; Dioxygen; Exact sciences and technology; General and physical chemistry; N-hydroxyphthalimide (NHPI); Oxidation; Oxidizing catalysts; Phthalimide-N-oxyl (PINO); Radicals; Selective oxidation; Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry; Transformations; Transforms; Versatility; Substrate; Selective oxidation; Catalytic reaction; Phthalimide-N-oxyl (PINO); Oxidizing catalysts; Oxidation; Review; N-hydroxyphthalimide (NHPI); Catalyst; Dioxygen
• ISSN: 0161-4940; 1520-5703
• DOI: 10.1080/01614940902743841

The last two decades represents a "start line" for the worldwide chemists, to develop new oxidizing methods, to replace the "old-fashioned" ones, which are expensive, pollute the environment, and proceed in harsh conditions. One of the best candidates to satisfy the present global needs is N-hydroxyphthalimide (NHPI), which can be used as a catalytic reagent successfully in a wide range of organic transformations. In this article, a review of the most frequently used methods to transform the NHPI into its nitroxyl radical correspondent, and the use of this powerful catalytic agent into various organic transformations, are presented.