Usefulness of Tacrolimus versus Cyclosporine after pediatric heart transplantation

This study compared the early clinical course of 9 pediatric heart transplantation recipients treated with cyclosporine A-based immunosuppression with 10 similarly aged recipients treated with tacrolimus-based therapy. One-year follow-up after transplantation revealed that tacrolimus-treated childre...

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Bibliographic Details
Published inThe American journal of cardiology Vol. 82; no. 4; pp. 541 - 543
Main Authors Herzberg, GilbertZ, Rossi, AnthonyF, Courtney, Mary, Lansman, StevenL, Gelb, BruceD, Parness, IraA, Lai, WymanW
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 15.08.1998
Elsevier
Elsevier Limited
Subjects
Adolescent
Biological and medical sciences
Cardiology
Child
Cyclosporine - therapeutic use
Drug therapy
Echocardiography
Female
Follow-Up Studies
Heart
Heart Transplantation
Humans
Immunomodulators
Immunosuppressive Agents - therapeutic use
Male
Medical sciences
Pediatrics
Pharmacology. Drug treatments
Tacrolimus - therapeutic use
Transplants & implants
Treatment Outcome
Human
Heart
Transplantation
Homotransplantation
Prevention
Rejection
Chemotherapy
Treatment
Tacrolimus
Follow up study
Surgery
Complication
Ciclosporin
Immunosuppressive agent
Child
Comparative study
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Summary:This study compared the early clinical course of 9 pediatric heart transplantation recipients treated with cyclosporine A-based immunosuppression with 10 similarly aged recipients treated with tacrolimus-based therapy. One-year follow-up after transplantation revealed that tacrolimus-treated children had similar left ventricular function, experienced fewer episodes of severe rejection, were more rapidly weaned from corticosteroids, and had relatively few side effects from immunosuppression compared with cyclosporine A-treated children.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(98)00380-4