Reduced incidence of invasive pneumococcal disease after introduction of the 13-valent conjugate vaccine in Navarre, Spain, 2001–2013

• Published in: Vaccine Vol. 32; no. 22; pp. 2553 - 2562
• Main Authors: Guevara, Marcela, Ezpeleta, Carmen, Gil-Setas, Alberto, Torroba, Luis, Beristain, Xabier, Aguinaga, Aitziber, García-Irure, José Javier, Navascués, Ana, García-Cenoz, Manuel, Castilla, Jesús
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 07.05.2014; Elsevier; Elsevier Limited
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Allergy and Immunology; Applied microbiology; Bacterial diseases; Bacteriology; Biological and medical sciences; Child; Child, Preschool; Children & youth; Female; Fundamental and applied biological sciences. Psychology; Human bacterial diseases; Humans; Immunization; Impact; Incidence; Infant; Infectious diseases; Invasive pneumococcal disease; Male; Medical sciences; Meningitis; Microbiology; Middle Aged; Miscellaneous; Pneumococcal conjugate vaccine; Pneumococcal Infections - epidemiology; Pneumococcal Infections - prevention & control; Pneumococcal Vaccines - administration & dosage; Pneumonia; Public health surveillance; Sentinel Surveillance; Spain - epidemiology; Staphylococcal infections, streptococcal infections, pneumococcal infections; Streptococcus pneumoniae; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vaccines, Conjugate - administration & dosage; Young Adult; Southern Europe; Europe; Spain; Impact; Pneumococcal conjugate vaccine; Invasive pneumococcal disease; Public health surveillance; Streptococcus pneumoniae; Vaccine; Epidemiology; Incidence; Infection; Streptococcaceae; Streptococcal infection; Bacteriosis; Bacteria; Micrococcales; Pneumococcal infection; Public health
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2014.03.054

Highlights • We analyse the trend of invasive pneumococcal disease in the 13-valent vaccine era. • The incidence of cases has declined notably in children and moderately in adults. • The incidence of cases due to vaccine serotypes decreased 81% in children <5 years. • The moderate decline in adults suggests the indirect effect of vaccination. • No changes indicating serotype replacement have been detected.