NOVEL ANTITUMOR ANTIBIOTIC PHOSPHOLINE 2. STRUCTURE DETERMINATION

Phospholine, an antitumor antibiotic, has the molecular formula of C25H40NO8P and posesses a δ-lactone and a phospholic acid ester as functional groups. Its structure was determined based on interpretation of fast atom bombardment MS, 1H NMR, 13C NMR, 1H-1H correlation spectroscopy (COSY), 13C-1H CO...

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Published inJournal of antibiotics Vol. 42; no. 9; pp. 1339 - 1343
Main Authors OZASA, TERUAKI, TANAKA, KOUICHI, SASAMATA, MIHO, KANIWA, HIDETOSHI, SHIMIZU, MINORU, MATSUMOTO, HISAO, IWANAMI, MASARU
Format Journal Article
LanguageEnglish
Published Japan JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1989
Subjects
Antibiotics, Antineoplastic - analysis
Antibiotics, Antineoplastic - isolation & purification
antitumor antibiotics
Chemical Phenomena
Chemistry
Lactones - isolation & purification
Magnetic Resonance Spectroscopy
Organophosphorus Compounds - isolation & purification
Streptomyces hygroscopicus
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Summary:Phospholine, an antitumor antibiotic, has the molecular formula of C25H40NO8P and posesses a δ-lactone and a phospholic acid ester as functional groups. Its structure was determined based on interpretation of fast atom bombardment MS, 1H NMR, 13C NMR, 1H-1H correlation spectroscopy (COSY), 13C-1H COSY, heteronuclear multiple bond correlation spectroscopy, elemental analysis and chemical modifications.
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ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.42.1339